4mpw: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Human beta-tryptase co-crystal structure with [(1,1,3,3-tetramethyldisiloxane-1,3-diyl)di-1-benzofuran-3,5-diyl]bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)==

~~The entry~~ 4mpw is ~~ON HOLD until Mar 18 2016~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4mpw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MPW OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MPW FirstGlance].

~~Authors~~: ~~White~~, A., ~~Stein~~, A.J., ~~Suto~~, R.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=2AJ:[(1,1,3,3-TETRAMETHYLDISILOXANE-1,3-DIYL)DI-1-BENZOFURAN-3,5-DIYL]BIS({4-[3-(AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}METHANONE)'>2AJ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>

~~Description~~:

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mpw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mpw RCSB], [http://www.ebi.ac.uk/pdbsum/4mpw PDBsum]</td></tr>

[[Category: Stein, A.J]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).

__TOC__

</StructureSection>

[[Category: Tryptase]]

[[Category: Stein, A J]]

[[Category: Suto, R]]

[[Category: White, A]]

[[Category: ~~Suto, R~~]]

[[Category: Alpha-hydroxyketone]]

[[Category: Coferon]]

[[Category: Crystal catalysis]]

[[Category: Drug discovery]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Self-assembly]]

[[Category: Silanol]]

[[Category: Small molecule inhibitor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Human beta-tryptase co-crystal structure with [(1,1,3,3-tetramethyldisiloxane-1,3-diyl)di-1-benzofuran-3,5-diyl]bis({4-[3-(aminomethyl)phenyl]piperidin-1-yl}methanone)==
+<StructureSection load='4mpw' size='340' side='right' caption='[[4mpw]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-The entry 4mpw is ON HOLD  until Mar 18 2016
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4mpw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MPW FirstGlance]. <br>
-Authors: White, A., Stein, A.J., Suto, R.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2AJ:[(1,1,3,3-TETRAMETHYLDISILOXANE-1,3-DIYL)DI-1-BENZOFURAN-3,5-DIYL]BIS({4-[3-(AMINOMETHYL)PHENYL]PIPERIDIN-1-YL}METHANONE)'>2AJ</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mpu|4mpu]], [[4mpv|4mpv]], [[4mpx|4mpx]], [[4mqa|4mqa]]</td></tr>
-Description:
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mpw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4mpw RCSB], [http://www.ebi.ac.uk/pdbsum/4mpw PDBsum]</span></td></tr>
-[[Category: Stein, A.J]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TRYB1_HUMAN TRYB1_HUMAN]] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Tryptase]]
+[[Category: Stein, A J]]
+[[Category: Suto, R]]
 [[Category: White, A]]
-[[Category: Suto, R]]
+[[Category: Alpha-hydroxyketone]]
+[[Category: Coferon]]
+[[Category: Crystal catalysis]]
+[[Category: Drug discovery]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Self-assembly]]
+[[Category: Silanol]]
+[[Category: Small molecule inhibitor]]