2r3f: Difference between revisions

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[[Image:2r3f.jpg|left|200px]]<br /><applet load="2r3f" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2r3f.jpg|left|200px]]
caption="2r3f, resolution 1.50&Aring;" />
 
'''Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor'''<br />
{{Structure
|PDB= 2r3f |SIZE=350|CAPTION= <scene name='initialview01'>2r3f</scene>, resolution 1.50&Aring;
|SITE= <scene name='pdbsite=AC1:Ace+Binding+Site+For+Residue+A+0'>AC1</scene> and <scene name='pdbsite=AC2:Sc8+Binding+Site+For+Residue+A+501'>AC2</scene>
|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> and <scene name='pdbligand=SC8:'>SC8</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22]
|GENE= CDK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
}}
 
'''Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2R3F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ACE:'>ACE</scene> and <scene name='pdbligand=SC8:'>SC8</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3F OCA].  
2R3F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3F OCA].  


==Reference==
==Reference==
Structure-guided discovery of cyclin-dependent kinase inhibitors., Fischmann TO, Hruza A, Duca JS, Ramanathan L, Mayhood T, Windsor WT, Le HV, Guzi TJ, Dwyer MP, Paruch K, Doll RJ, Lees E, Parry D, Seghezzi W, Madison V, Biopolymers. 2007 Oct 15;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17937404 17937404]
Structure-guided discovery of cyclin-dependent kinase inhibitors., Fischmann TO, Hruza A, Duca JS, Ramanathan L, Mayhood T, Windsor WT, Le HV, Guzi TJ, Dwyer MP, Paruch K, Doll RJ, Lees E, Parry D, Seghezzi W, Madison V, Biopolymers. 2007 Oct 15;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17937404 17937404]
[[Category: Cyclin-dependent kinase]]
[[Category: Cyclin-dependent kinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: transferase]]
[[Category: transferase]]


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