3wso: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of the Skp1-FBG3 complex==
 
<StructureSection load='3wso' size='340' side='right' caption='[[3wso]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
The entry 3wso is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3wso]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WSO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WSO FirstGlance]. <br>
Authors: Kumonomidou, T., Nishio, K., Takagi, K., Nakagawa, T., Suzuki, A., Yamane, T, Tokunaga, F., Iwai, K., Murakami, A., Yoshida, Y., Tanaka, K., Mizushima, T.
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2e31|2e31]]</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wso OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wso RCSB], [http://www.ebi.ac.uk/pdbsum/3wso PDBsum]</span></td></tr>
Description: Crystal structure of the Skp1-FBG3 complex
</table>
[[Category: Unreleased Structures]]
== Function ==
[[http://www.uniprot.org/uniprot/FBX44_HUMAN FBX44_HUMAN]] Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. [[http://www.uniprot.org/uniprot/SKP1_HUMAN SKP1_HUMAN]] Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.<ref>PMID:16209941</ref> <ref>PMID:20181953</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Iwai, K]]
[[Category: Kumonomidou, T]]
[[Category: Kumonomidou, T]]
[[Category: Iwai, K]]
[[Category: Mizushima, T]]
[[Category: Murakami, A]]
[[Category: Nakagawa, T]]
[[Category: Nishio, K]]
[[Category: Nishio, K]]
[[Category: Yamane, T, Tokunaga, F]]
[[Category: Nakagawa, T]]
[[Category: Suzuki, A]]
[[Category: Suzuki, A]]
[[Category: Takagi, K]]
[[Category: Tanaka, K]]
[[Category: Tanaka, K]]
[[Category: Mizushima, T]]
[[Category: Tokunaga, F]]
[[Category: Yamane, T]]
[[Category: Yoshida, Y]]
[[Category: Yoshida, Y]]
[[Category: Takagi, K]]
[[Category: F-box protein]]
[[Category: Murakami, A]]
[[Category: Ligase]]
[[Category: Scf ubiquitin ligase]]
[[Category: Skp1]]
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