4oiv: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structural basis for small molecule NDB as a selective antagonist of FXR==

~~The entry~~ 4oiv is ~~ON HOLD until Mar 20 2016~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4oiv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OIV FirstGlance]. <br>

~~Authors~~: Xu, X., ~~Chen~~, L.~~, Hu, L~~.~~, Shen, X~~.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XX9:N-BENZYL-N-(3-TERT-BUTYL-4-HYDROXYPHENYL)-2,6-DICHLORO-4-(DIMETHYLAMINO)BENZAMIDE'>XX9</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oiv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oiv RCSB], [http://www.ebi.ac.uk/pdbsum/4oiv PDBsum]</span></td></tr>

~~Description~~: ~~Structural basis~~ for ~~small molecule NDB~~ as ~~a selective antagonist~~ of ~~FXR~~

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Chen, L]]

[[Category: Hu, L]]

[[Category: Shen, X]]

~~[[Category: Hu, L]]~~

[[Category: Xu, X]]

[[Category: ~~Chen, L~~]]

[[Category: Bile acid sensor]]

[[Category: Nuclear]]

[[Category: Nuclear protein receptor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structural basis for small molecule NDB as a selective antagonist of FXR==
+<StructureSection load='4oiv' size='340' side='right' caption='[[4oiv]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-The entry 4oiv is ON HOLD  until Mar 20 2016
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4oiv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OIV FirstGlance]. <br>
-Authors: Xu, X., Chen, L., Hu, L., Shen, X.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XX9:N-BENZYL-N-(3-TERT-BUTYL-4-HYDROXYPHENYL)-2,6-DICHLORO-4-(DIMETHYLAMINO)BENZAMIDE'>XX9</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oiv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oiv RCSB], [http://www.ebi.ac.uk/pdbsum/4oiv PDBsum]</span></td></tr>
-Description: Structural basis for small molecule NDB as a selective antagonist of FXR
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
+[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Chen, L]]
+[[Category: Hu, L]]
 [[Category: Shen, X]]
-[[Category: Hu, L]]
 [[Category: Xu, X]]
-[[Category: Chen, L]]
+[[Category: Bile acid sensor]]
+[[Category: Nuclear]]
+[[Category: Nuclear protein receptor]]