Sandbox Reserved 1058: Difference between revisions

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Isocitrate lyase plays a key role in survival of ''M. tuberculosis'' by sustaining intracellular infections in inflammatory respiratory macrophages. Used in the citric acid cycle, isocitrate lyase is the first enzyme catalyzing the carbon conserving glyoxylate pathway. This glyoxylate pathway has not been observed in mammals and thus presents a unique drug target to solely attack TB infections.  
Isocitrate lyase plays a key role in survival of ''M. tuberculosis'' by sustaining intracellular infections in inflammatory respiratory macrophages. Used in the citric acid cycle, isocitrate lyase is the first enzyme catalyzing the carbon conserving glyoxylate pathway. This glyoxylate pathway has not been observed in mammals and thus presents a unique drug target to solely attack TB infections.  


 
==Protein Structure==
===Wild Type Protein===
===Crystal Structure===
===3-Bromopyruvate===
[[Image:Normal_Crystal_Structure.png|300 px|center|thumb|Figure Legend]]
===3-Nitopropionate===
<StructureSection load='1F8I' size='340' side='right' caption='Isocitrate Lyase' scene='>
<StructureSection load='1F8I' size='340' side='right' caption='Isocitrate Lyase' scene='>
This is a default text for your page '''Perry Rabin/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
== Structure ==
[[Image:Normal_Crystal_Structure.png|300 px|center|thumb|Figure Legend]]


== Function ==
== Function ==
== Disease ==


== Structural highlights ==
== Structural highlights ==
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