Myoglobin: Difference between revisions
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<StructureSection load='1a6m' size='350' side='right' caption='Structure of Sperm whale myoglobin with O2 and sulfate (PDB entry [[1a6m]])' scene=''> | <StructureSection load='1a6m' size='350' side='right' caption='Structure of Sperm whale myoglobin with O2 and sulfate (PDB entry [[1a6m]])' scene=''> | ||
[[Myoglobin]] is a globular protein whose function is to store molecular oxygen in muscles (myo = muscles). It has two main components: a single polypeptide chain, and heme ligand. The heme ligand is only <scene name='23/238129/Transparent_spacefill/2'>partially exposed</scene> to the surface; the majority of it is buried inside the protein. | [[Myoglobin]] is a globular protein whose function is to store molecular oxygen in muscles (myo = muscles). It has two main components: a single polypeptide chain, and heme ligand. The heme ligand is only <scene name='23/238129/Transparent_spacefill/2'>partially exposed</scene> to the surface; the majority of it is buried inside the protein. The overall <scene name='23/238129/Surface/1'>shape</scene> of myoglobin is approximately disc-shaped with a diameter that is about twice its thickness. The overall fold of the protein is conserved, especially the <scene name='23/238129/Hydrophobic/1'>hydrophobic</scene> core of the protein (shown in purple), but the sequence is more <scene name='23/238129/Conserved_cartoon/1'>variable</scene> on the surface. {{Template:ColorKey_ConSurf}} | ||
The globin consists mostly of [[Helices in Proteins|alpha helices]] shown in <scene name='23/238129/2ndary_structure/2'>pink</scene>; it has no beta sheets and its nonhelical segments mostly serve as links that connect the helices. Look down the barrel of some of the longer helices. Are they all straight? The eight structurally conserved alpha helices are labelled <scene name='23/238129/Helix_labels/2'>A through H</scene>. The protein is colored as a N-->C rainbow in this view; the N terminus is blue, while the C terminus is red. | The globin consists mostly of [[Helices in Proteins|alpha helices]] shown in <scene name='23/238129/2ndary_structure/2'>pink</scene>; it has no beta sheets and its nonhelical segments mostly serve as links that connect the helices. Look down the barrel of some of the longer helices. Are they all straight? The eight structurally conserved alpha helices are labelled <scene name='23/238129/Helix_labels/2'>A through H</scene>. The protein is colored as a N-->C rainbow in this view; the N terminus is blue, while the C terminus is red. | ||
