4yyx

Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin2 C-terminal tail

spinqualitylabelsall models 4yyx, resolution 1.79Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4yyx is a 2 chain structure. This structure supersedes the now removed PDB entry 4oeq. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: FMT Related: 4oeo, 4oep Resources: FirstGlance, OCA, RCSB, PDBsum Function [ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.

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