4xc5: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==CRYSTAL STRUCTURE OF THE T1L REOVIRUS ATTACHMENT PROTEIN SIGMA1==

~~The entry~~ 4xc5 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4xc5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC5 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC5 FirstGlance].

~~Authors~~: ~~Reiss~~, K., ~~Stehle~~, T.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

~~Description~~: ~~CRYSTAL STRUCTURE OF THE T1L REOVIRUS ATTACHMENT PROTEIN SIGMA1~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xc5 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc5 PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).

__TOC__

</StructureSection>

[[Category: Reiss, K]]

[[Category: Stehle, T]]

[[Category: ~~Reiss, K~~]]

[[Category: 3-sialyllactose]]

[[Category: Beta-barrel]]

[[Category: Beta-spiral repeat]]

[[Category: Gm2 glycan alpha-2]]

[[Category: Greek key motif]]

[[Category: Junctional adhesion molecule some]]

[[Category: Triple beta-spiral]]

[[Category: Viral attachment protein]]

[[Category: Viral capsid]]

[[Category: Viral protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==CRYSTAL STRUCTURE OF THE T1L REOVIRUS ATTACHMENT PROTEIN SIGMA1==
+<StructureSection load='4xc5' size='340' side='right' caption='[[4xc5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-The entry 4xc5 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4xc5]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XC5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XC5 FirstGlance]. <br>
-Authors: Reiss, K., Stehle, T.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3s6x|3s6x]], [[1kke|1kke]], [[4gu3|4gu3]], [[4odb|4odb]], [[3eoy|3eoy]]</td></tr>
-Description: CRYSTAL STRUCTURE OF THE T1L REOVIRUS ATTACHMENT PROTEIN SIGMA1
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xc5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xc5 RCSB], [http://www.ebi.ac.uk/pdbsum/4xc5 PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/SIGM1_REOVL SIGM1_REOVL]] Fiber-like molecule that attaches the virion to the host cell membrane by binding to the primary receptor F11R/JAM-A and to sialic acid containing proteins (coreceptor). The interaction of sigma-1 with F11R is required for NF-kB activation and apoptosis. Binding to both sialic acid and F11R is required to induce maximal levels of apoptosis (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Reiss, K]]
 [[Category: Stehle, T]]
-[[Category: Reiss, K]]
+[[Category: 3-sialyllactose]]
+[[Category: Beta-barrel]]
+[[Category: Beta-spiral repeat]]
+[[Category: Gm2 glycan alpha-2]]
+[[Category: Greek key motif]]
+[[Category: Junctional adhesion molecule some]]
+[[Category: Triple beta-spiral]]
+[[Category: Viral attachment protein]]
+[[Category: Viral capsid]]
+[[Category: Viral protein]]