4yru: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus==

~~The entry~~ 4yru is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4yru]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YRU FirstGlance]. <br>

~~Authors~~: ~~Pandalaneni~~, S., ~~Karrupiah~~, V., ~~Mayans~~, O.~~, Derrick, J~~.P.~~, Lian, L~~.Y.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yru RCSB], [http://www.ebi.ac.uk/pdbsum/4yru PDBsum]</span></td></tr>

~~Description:~~

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[http://www.uniprot.org/uniprot/NCS1_RAT NCS1_RAT]] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.<ref>PMID:17502602</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Derrick, J P]]

[[Category: Karrupiah, V]]

[[Category: Lian, L Y]]

[[Category: Mayans, O]]

[[Category: Pandalaneni, S]]

[[Category: ~~Lian, L.Y~~]]

[[Category: C-terminal truncation]]

[[Category: ~~Mayans, O~~]]

[[Category: Calcium sensor]]

[[Category: ~~Derrick, J.P~~]]

[[Category: Ef-hand]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of C-terminally truncated Neuronal Calcium Sensor (NCS-1) from Rattus norvegicus==
+<StructureSection load='4yru' size='340' side='right' caption='[[4yru]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-The entry 4yru is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4yru]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YRU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YRU FirstGlance]. <br>
-Authors: Pandalaneni, S., Karrupiah, V., Mayans, O., Derrick, J.P., Lian, L.Y.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yru OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yru RCSB], [http://www.ebi.ac.uk/pdbsum/4yru PDBsum]</span></td></tr>
-Description:
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
+[[http://www.uniprot.org/uniprot/NCS1_RAT NCS1_RAT]] Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel.<ref>PMID:17502602</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Derrick, J P]]
 [[Category: Karrupiah, V]]
+[[Category: Lian, L Y]]
+[[Category: Mayans, O]]
 [[Category: Pandalaneni, S]]
-[[Category: Lian, L.Y]]
+[[Category: C-terminal truncation]]
-[[Category: Mayans, O]]
+[[Category: Calcium sensor]]
-[[Category: Derrick, J.P]]
+[[Category: Ef-hand]]
+[[Category: Signaling protein]]