2rjs: Difference between revisions
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[[Image:2rjs.jpg|left|200px]] | [[Image:2rjs.jpg|left|200px]] | ||
'''SgTAM bound to substrate mimic''' | {{Structure | ||
|PDB= 2rjs |SIZE=350|CAPTION= <scene name='initialview01'>2rjs</scene>, resolution 2.400Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=296:'>296</scene> | |||
|ACTIVITY= [http://en.wikipedia.org/wiki/Tyrosine_2,3-aminomutase Tyrosine 2,3-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.6 5.4.3.6] | |||
|GENE= SgcC4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1908 Streptomyces globisporus]) | |||
}} | |||
'''SgTAM bound to substrate mimic''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2RJS is a [ | 2RJS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJS OCA]. | ||
==Reference== | ==Reference== | ||
Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM., Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD, Bioorg Med Chem Lett. 2007 Nov 19;. PMID:[http:// | Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM., Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD, Bioorg Med Chem Lett. 2007 Nov 19;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18078753 18078753] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptomyces globisporus]] | [[Category: Streptomyces globisporus]] | ||
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[[Category: mio]] | [[Category: mio]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:36:51 2008'' | ||
Revision as of 16:36, 20 March 2008
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| 2rjs, resolution 2.400Å | |||||||||||||
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| Ligands: | 296 | ||||||||||||
| Gene: | SgcC4 (Streptomyces globisporus) | ||||||||||||
| Activity: | Tyrosine 2,3-aminomutase, with EC number 5.4.3.6 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
SgTAM bound to substrate mimic
Overview
The synthesis and evaluation of two classes of inhibitors for SgTAM, a 4-methylideneimidazole-5-one (MIO) containing tyrosine aminomutase, are described. A mechanism-based strategy was used to design analogs that mimic the substrate or product of the reaction and form covalent interactions with the enzyme through the MIO prosthetic group. The analogs were characterized by measuring inhibition constants and X-ray crystallographic structural analysis of the co-complexes bound to the aminomutase, SgTAM.
About this Structure
2RJS is a Single protein structure of sequence from Streptomyces globisporus. Full crystallographic information is available from OCA.
Reference
Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM., Montavon TJ, Christianson CV, Festin GM, Shen B, Bruner SD, Bioorg Med Chem Lett. 2007 Nov 19;. PMID:18078753
Page seeded by OCA on Thu Mar 20 18:36:51 2008
