2rkd: Difference between revisions

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[[Image:2rkd.jpg|left|200px]]<br /><applet load="2rkd" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2rkd.jpg|left|200px]]
caption="2rkd, resolution 1.900&Aring;" />
 
'''The Structure of rat cytosolic PEPCK in complex with 3-phosphonopropionate'''<br />
{{Structure
|PDB= 2rkd |SIZE=350|CAPTION= <scene name='initialview01'>2rkd</scene>, resolution 1.900&Aring;
|SITE= <scene name='pdbsite=AC1:Mn+Binding+Site+For+Residue+A+700'>AC1</scene>, <scene name='pdbsite=AC2:Mn+Binding+Site+For+Residue+A+701'>AC2</scene>, <scene name='pdbsite=AC3:Na+Binding+Site+For+Residue+A+702'>AC3</scene> and <scene name='pdbsite=AC4:3pp+Binding+Site+For+Residue+A+703'>AC4</scene>
|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=3PP:3-PHOSPHONOPROPANOIC ACID'>3PP</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxykinase_(GTP) Phosphoenolpyruvate carboxykinase (GTP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.32 4.1.1.32]
|GENE= Pck1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
}}
 
'''The Structure of rat cytosolic PEPCK in complex with 3-phosphonopropionate'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2RKD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=MN:'>MN</scene>, <scene name='pdbligand=NA:'>NA</scene> and <scene name='pdbligand=3PP:'>3PP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxykinase_(GTP) Phosphoenolpyruvate carboxykinase (GTP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.32 4.1.1.32] Known structural/functional Sites: <scene name='pdbsite=AC1:Mn+Binding+Site+For+Residue+A+700'>AC1</scene>, <scene name='pdbsite=AC2:Mn+Binding+Site+For+Residue+A+701'>AC2</scene>, <scene name='pdbsite=AC3:Na+Binding+Site+For+Residue+A+702'>AC3</scene> and <scene name='pdbsite=AC4:3pp+Binding+Site+For+Residue+A+703'>AC4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RKD OCA].  
2RKD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RKD OCA].  


==Reference==
==Reference==
Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition., Stiffin RM, Sullivan SM, Carlson GM, Holyoak T, Biochemistry. 2008 Feb 19;47(7):2099-109. Epub 2008 Jan 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18197707 18197707]
Differential Inhibition of Cytosolic PEPCK by Substrate Analogues. Kinetic and Structural Characterization of Inhibitor Recognition., Stiffin RM, Sullivan SM, Carlson GM, Holyoak T, Biochemistry. 2008 Feb 19;47(7):2099-109. Epub 2008 Jan 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18197707 18197707]
[[Category: Phosphoenolpyruvate carboxykinase (GTP)]]
[[Category: Phosphoenolpyruvate carboxykinase (GTP)]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: nucleotide-binding]]
[[Category: nucleotide-binding]]


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