Sandbox Reserved 1066: Difference between revisions
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= Introduction = | = Introduction = | ||
''Mycobacterium tuberculosis'' very-long-chain fatty acyl-CoA synthetase, also known as FadD13, is unique within its class in regards to its ability to house lipid substrates longer than itself. Most FadD class proteins exist as integral membrane proteins involved in lipid transport into the cell. FadD13 is unique structurally in that it exists as a peripheral protein on the inside of the cell membrane. This feature is key in the mechanistic basis for FadD13's activation and transport of fatty acids of length C24-C26 through the two step addition of [ | ''Mycobacterium tuberculosis'' very-long-chain fatty acyl-CoA synthetase, also known as FadD13, is unique within its class in regards to its ability to house lipid substrates longer than itself. Most FadD class proteins exist as integral membrane proteins involved in lipid transport into the cell. FadD13 is unique structurally in that it exists as a peripheral protein on the inside of the cell membrane. This feature is key in the mechanistic basis for FadD13's activation and transport of fatty acids of length C24-C26 through the two step addition of [http://en.wikipedia.org/wiki/Coenzyme_A Coenzyme A](Figure 1).<ref name="Our Paper">PMID: 22560731</ref> | ||
FadD13 may be important in the virulence of [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis ''Mycobacterium tuberculosis''], the etiological agent of [https://en.wikipedia.org/wiki/Tuberculosis tuberculosis], and has emerged as possible target for novel therapeutic agents.<ref name="JT">PMID: 20454815</ref> | FadD13 may be important in the virulence of [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis ''Mycobacterium tuberculosis''], the etiological agent of [https://en.wikipedia.org/wiki/Tuberculosis tuberculosis], and has emerged as possible target for novel therapeutic agents.<ref name="JT">PMID: 20454815</ref> | ||
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[https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis ''Mycobacterium tuberculosis''] Wikipedia page | [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis ''Mycobacterium tuberculosis''] Wikipedia page | ||
[ | [http://en.wikipedia.org/wiki/Coenzyme_A Coenzyme A] Wikipedia page | ||
[https://en.wikipedia.org/wiki/Mycolic_acid Mycolic Acid] Wikipedia page | [https://en.wikipedia.org/wiki/Mycolic_acid Mycolic Acid] Wikipedia page | ||
