Sandbox Reserved 433: Difference between revisions
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==Binding Interactions== | ==Binding Interactions== | ||
1)Folding of protein | 1)Folding of protein | ||
a) location and description of position of alpha and beta sheets (Show in separate color on green screen) | a) location and description of position of alpha and beta sheets (Show in separate color on green screen) | ||
b) crystal structure data (Table 1, Structural Characterizaiton of the GSK-3B Active Site Using Selective and Non-selective ATP-mimetic Inhibitors) | b) crystal structure data (Table 1, Structural Characterizaiton of the GSK-3B Active Site Using Selective and Non-selective ATP-mimetic Inhibitors) | ||
2)Substrate binding | 2)Substrate binding | ||
a) “phosphate-binding” pocket: describe three crucial basic residues (Show in different color on green screen) | a) “phosphate-binding” pocket: describe three crucial basic residues (Show in different color on green screen) | ||
b) GSK-3 substrates and binding specifics- S/TxxxS/T (S=Serine, T=threonine, X= any amino acid) | b) GSK-3 substrates and binding specifics- S/TxxxS/T (S=Serine, T=threonine, X= any amino acid) | ||
