Sandbox Reserved 987: Difference between revisions
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Finding a therapeutic agent to combat cocaine, such as small molecules has proven difficult. For this reason, the focus has been switched to cocaine esterases. For over a decade, cocaine esterases have been studied and numerous findings strongly suggest that bacterial cocaine esterases should provide a safe and effective method to rapidly eliminate the symptoms of acute cocaine intoxication in humans, as well as reducing addictiveness to the drug. | Finding a therapeutic agent to combat cocaine, such as small molecules has proven difficult. For this reason, the focus has been switched to cocaine esterases. For over a decade, cocaine esterases have been studied and numerous findings strongly suggest that bacterial cocaine esterases should provide a safe and effective method to rapidly eliminate the symptoms of acute cocaine intoxication in humans, as well as reducing addictiveness to the drug. | ||
As an example, there was a test done involving rhesus-monkeys and the effects of CocE on the brain after cocaine uptake.<sup><ref>A thermostable bacterial cocaine esterase rapidly eliminates cocaine from brain in nonhuman primates.LL Howell, JA Nye, JS Stehouwer, RJ Voll, J Mun, D Narasimhan, J Nichols, R Sunahara, MM Goodman, FI Carroll and JH Woods</ref></sup> The study was the first to evaluate the effects of CocE on cocaine brain levels. Positron emission tomography (PET) neuroimaging was used to evaluate the time course of cocaine elimination from the brain of rhesus-monkeys in the presence and absence of CocE. | As an example, there was a test done involving rhesus-monkeys and the effects of CocE on the brain after cocaine uptake.<sup><ref>A thermostable bacterial cocaine esterase rapidly eliminates cocaine from brain in nonhuman primates.LL Howell, JA Nye, JS Stehouwer, RJ Voll, J Mun, D Narasimhan, J Nichols, R Sunahara, MM Goodman, FI Carroll and JH Woods</ref></sup> The study was the first to evaluate the effects of CocE on cocaine brain levels. Positron emission tomography (PET) neuroimaging was used to evaluate the time course of cocaine elimination from the brain of rhesus-monkeys in the presence and absence of CocE. PET scans of the rhesus-monkey brain show that just after 15 minutes of being exposed to CocE almost all the brain activity caused by cocaine has diminished; much more so opposed to saline solution. This data further supports the development of CocE for the treatment of acute cocaine toxicity. | ||
PET scans of the rhesus-monkey brain show that just after 15 minutes of being exposed to CocE almost all the brain activity caused by cocaine has diminished; much more so opposed to saline solution. This data further supports the development of CocE for the treatment of acute cocaine toxicity. | |||
== References == | == References == | ||
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