Sandbox Reserved 433: Difference between revisions

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<scene name='48/483890/Overall_structure_of_gsk-3beta/3'>Green Scene for Overall Structure</scene>
<scene name='48/483890/Overall_structure_of_gsk-3beta/3'>Green Scene for Overall Structure</scene>
==Binding Interactions==
==Binding Interactions==
1)Folding of protein


a) location and description of position of alpha and beta sheets (Show in separate color on green screen)
<scene name='48/483890/Binding_interactions/1'> Alignment of Arg 96, Arg 180, and Lys 205 when GSK-3β is active </scene>
 
b) crystal structure data (Table 1, Structural Characterizaiton of the GSK-3B Active Site Using Selective and Non-selective ATP-mimetic Inhibitors)
 
2)Substrate binding
 
a)  “phosphate-binding” pocket: describe three crucial basic residues (Show in different color on green screen)
 
b)  GSK-3 substrates and binding specifics- S/TxxxS/T (S=Serine, T=threonine, X= any amino acid)
 
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217193/
http://www.rcsb.org/pdb/explore/explore.do?pdbId=1Q3D


==Additional Features==
==Additional Features==
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