Sandbox Reserved 433: Difference between revisions
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==Introduction== | ==Introduction== | ||
'''Glycogen synthase kinase-3''', or '''GSK-3''', is one of the main proteins that controls the activation of glycogen synthase. GSK-3 is serine/threonine protein kinase which regulates the phosphorylation of serine and threonine molecules. Serine/threonine kinase is important for the regulation of cell proliferation, cell death, cell differentiation, and embryonic development<ref>PMID: 16912193</ref>. GSK-3 is found in two forms, GSK-3β and GSK-3α. The two forms have different functions with GSK-3 β involved in energy metabolism, neuronal cell development, and body pattern formation, while GSK-3α has more function with WNT signaling pathways, which controls cell fate. This proteopedia page will be focused on GSK-3β. The GSK-3β is found in most mammals, all with similar structure and function. In experiments when GSK-3β was perturbed in mice, embryonic lethality during gestation was demonstrated<ref>PMID: 20599907</ref>. Recent research in regards to GSK-3β includes type II diabetes, Alzheimer's Disease, inflammation, cancer, and neurological disorders such as strokes and bipolar disorder. | '''Glycogen synthase kinase-3''', or '''GSK-3''', is one of the main proteins that controls the activation of glycogen synthase. GSK-3 is serine/threonine protein kinase which regulates the phosphorylation of serine and threonine molecules. Serine/threonine kinase is important for the regulation of cell proliferation, cell death, cell differentiation, and embryonic development<ref>PMID: 16912193</ref>. GSK-3 is found in two forms, GSK-3β and GSK-3α. The two forms have different functions with GSK-3 β involved in energy metabolism, neuronal cell development, and body pattern formation, while GSK-3α has more function with WNT signaling pathways, which controls cell fate. This proteopedia page will be focused on GSK-3β. The GSK-3β is found in most mammals, all with similar structure and function. In experiments when GSK-3β was perturbed in mice, embryonic lethality during gestation was demonstrated<ref>PMID: 20599907</ref>. Recent research in regards to GSK-3β includes type II diabetes, Alzheimer's Disease, inflammation, cancer, and neurological disorders such as strokes and bipolar disorder. | ||
GSK-3β has been shown to interact with various enzymes including: TGF- β1, Smad3, AKAP11, AXIN1, AXIN2, AR, CTNNB1, DNM1L, MACF1 MUC1, SMAD3, NOTCH1,NOTCH2, P53, PRKAR2A, SGK3, and TSC2. This page focuses on a GSK-3β complex with a Staurosporine inhibitor. Since ATP has a stronger affinity to binding to staurosporine than to protein kinases, the molecule acts a competitive inhibitor in regards to GSK-3β<ref name="paper">PMID: 14529625</ref>. | GSK-3β has been shown to interact with various enzymes including: TGF- β1, Smad3, AKAP11, AXIN1, AXIN2, AR, CTNNB1, DNM1L, MACF1 MUC1, SMAD3, NOTCH1,NOTCH2, P53, PRKAR2A, SGK3, and TSC2. This page focuses on a GSK-3β complex with a Staurosporine inhibitor. Since ATP has a stronger affinity to binding to staurosporine than to protein kinases, the molecule acts a competitive inhibitor in regards to GSK-3β<ref name="paper">PMID: 14529625</ref>. | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the complex. | |||
==Overall Structure== | ==Overall Structure== | ||
