4cv9: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==MPS1 kinase with 3-aminopyridin-2-one inhibitors==

~~The entry~~ 4cv9 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4cv9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CV9 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CV9 FirstGlance].

~~Authors~~: ~~Fearon~~, D., ~~Bavetsias~~, V., ~~Bayliss~~, R., ~~Schmitt~~, J., ~~Westwood~~, I.M., ~~vanMontfort~~, R.~~L.M~~., ~~Jones, K~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=W2K:4-(4-METHYLPIPERAZIN-1-YL)-N-(2-OXO-5-(PYRIDIN-4-YL)-1,2-DIHYDROPYRIDIN-3-YL)BENZAMIDE'>W2K</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>

~~Description~~: ~~MPS1~~ kinase ~~with 3-aminopyridin-2-one inhibitors~~

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4cv8|4cv8]], [[4cva|4cva]]</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </td></tr>

[[Category: ~~Vanmontfort~~, R~~.L.M~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cv9 RCSB], [http://www.ebi.ac.uk/pdbsum/4cv9 PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Dual-specificity kinase]]

[[Category: Bavetsias, V]]

[[Category: Bayliss, R]]

[[Category: Fearon, D]]

[[Category: Jones, K]]

[[Category: Schmitt, J]]

[[Category: ~~Jones~~, K]]

[[Category: Westwood, I M]]

[[Category: ~~Westwood~~, I.M]]

[[Category: VanMontfort, R L.M]]

[[Category: ~~Bavetsias, V~~]]

[[Category: Inhibitor]]

[[Category: ~~Bayliss, R~~]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==MPS1 kinase with 3-aminopyridin-2-one inhibitors==
+<StructureSection load='4cv9' size='340' side='right' caption='[[4cv9]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-The entry 4cv9 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4cv9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CV9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CV9 FirstGlance]. <br>
-Authors: Fearon, D., Bavetsias, V., Bayliss, R., Schmitt, J., Westwood, I.M., vanMontfort, R.L.M., Jones, K.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=W2K:4-(4-METHYLPIPERAZIN-1-YL)-N-(2-OXO-5-(PYRIDIN-4-YL)-1,2-DIHYDROPYRIDIN-3-YL)BENZAMIDE'>W2K</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-Description: MPS1 kinase with 3-aminopyridin-2-one inhibitors
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cv8|4cv8]], [[4cva|4cva]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
-[[Category: Vanmontfort, R.L.M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cv9 RCSB], [http://www.ebi.ac.uk/pdbsum/4cv9 PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Dual-specificity kinase]]
+[[Category: Bavetsias, V]]
+[[Category: Bayliss, R]]
 [[Category: Fearon, D]]
+[[Category: Jones, K]]
 [[Category: Schmitt, J]]
-[[Category: Jones, K]]
+[[Category: Westwood, I M]]
-[[Category: Westwood, I.M]]
+[[Category: VanMontfort, R L.M]]
-[[Category: Bavetsias, V]]
+[[Category: Inhibitor]]
-[[Category: Bayliss, R]]
+[[Category: Transferase]]