Sandbox Reserved 1071: Difference between revisions
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The location of the binding site for isoniazid (INH) is located near the ''delta meso'' heme edge, about 3.8 A away from the heme iron. This binding site is found within what is considered to be the usual substrate access channel of peroxidases. The reaction between INH and the enzyme must occur from interaction in a binding site intended for the natural substrate. Asp 137 plays a key role in the activation and binding of INH. Asp 137 creates energetically favorable interactions due to its ability to make hydrogen-bond interactions between its carboxylic acid side chain and the pyridinyl N1 of INH. | The location of the binding site for isoniazid (INH) is located near the ''delta meso'' heme edge, about 3.8 A away from the heme iron. This binding site is found within what is considered to be the usual substrate access channel of peroxidases. The reaction between INH and the enzyme must occur from interaction in a binding site intended for the natural substrate. Asp 137 plays a key role in the activation and binding of INH. Asp 137 creates energetically favorable interactions due to its ability to make hydrogen-bond interactions between its carboxylic acid side chain and the pyridinyl N1 of INH. | ||
[[Image:INH_structure._PNG.PNG|300 px|left|thumb|Figure Legend]] | |||
