Sandbox Reserved 1065: Difference between revisions

Revision as of 01:15, 9 April 2015 view source Joseph Thomas (talk \| contribs) 95 edits No edit summary ← Older edit		Revision as of 01:16, 9 April 2015 view source Joseph Thomas (talk \| contribs) 95 edits No edit summary Newer edit →
Line 11:		Line 11:
	=active site (to be copied over)=		=active site (to be copied over)=

	A high conserved residue in the C-terminal region, <scene name='69/694233/Lys_487/2'>Lysine 487</scene>, resulted in a 95% loss of function of FadD13 and is thought to be involved in the orientation of the substrates to form the adenylate intermediate.<ref name="residue paper">PMID: 20027301</ref> ~~Other mutation studies~~, ~~found that~~ Serine 404 was involved in the binding of Coenzyme A which may only occur once ~~the~~ region incurs a 140 degree rotational change.<ref name="Our Paper"/><ref name="residue paper"/>		Mutational studies showed that high conserved residue in the C-terminal region, <scene name='69/694233/Lys_487/2'>Lysine 487</scene>, resulted in a 95% loss of function of FadD13 and is thought to be involved in the orientation of the substrates to form the adenylate intermediate.<ref name="residue paper">PMID: 20027301</ref> Additionally, Serine 404 was hypothesized to be involved in the binding of Coenzyme A which may only occur once this region incurs a 140 degree rotational change.<ref name="Our Paper"/><ref name="residue paper"/>

Navigation menu