Sandbox Reserved 1066: Difference between revisions

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== General mechanism for the activation of fatty acids ==

FadD13 represents the first Fatty Acyl-CoA Synthetase of its kind to display biphasic kinetics.<ref name="residue paper"/> FadD13 first activates the fatty acid through a reaction with ATP to form an acyl adenylate intermediate and subsequently releases a pyrophosphate. Following a conformational change of the enzyme, coenzyme A is able to bind and ~~reaction~~ with the acyl adenylate intermediate forming the [http://en.wikipedia.org/wiki/Acyl-CoA acyl CoA] product (Figure 2). These activated fatty acyl-CoA thioesters have then been demonstrated to be important for the synthesis of triacyglycerols and phospholipids in the membrane of ''Mycobacterium tuberculosis''. <ref name="residue paper"/>

FadD13 represents the first Fatty Acyl-CoA Synthetase of its kind to display biphasic kinetics.<ref name="residue paper"/> FadD13 first activates the fatty acid through a reaction with ATP to form an acyl adenylate intermediate and subsequently releases a pyrophosphate. Following a conformational change of the enzyme upon the binding of ATP, coenzyme A is able to bind to its active site and react with the acyl adenylate intermediate forming the [http://en.wikipedia.org/wiki/Acyl-CoA acyl CoA] product (Figure 2). These activated fatty acyl-CoA thioesters have then been demonstrated to be important for the synthesis of triacyglycerols and phospholipids in the membrane of ''Mycobacterium tuberculosis''. <ref name="residue paper"/>

Sandbox Reserved 1066: Difference between revisions

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Revision as of 02:33, 9 April 2015 view source Stephanie Shoults (talk \| contribs) 81 edits No edit summary ← Older edit		Revision as of 02:36, 9 April 2015 view source Stephanie Shoults (talk \| contribs) 81 edits No edit summary Newer edit →
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	== General mechanism for the activation of fatty acids ==		== General mechanism for the activation of fatty acids ==
	FadD13 represents the first Fatty Acyl-CoA Synthetase of its kind to display biphasic kinetics.<ref name="residue paper"/> FadD13 first activates the fatty acid through a reaction with ATP to form an acyl adenylate intermediate and subsequently releases a pyrophosphate. Following a conformational change of the enzyme, coenzyme A is able to bind and ~~reaction~~ with the acyl adenylate intermediate forming the [http://en.wikipedia.org/wiki/Acyl-CoA acyl CoA] product (Figure 2). These activated fatty acyl-CoA thioesters have then been demonstrated to be important for the synthesis of triacyglycerols and phospholipids in the membrane of ''Mycobacterium tuberculosis''. <ref name="residue paper"/>		FadD13 represents the first Fatty Acyl-CoA Synthetase of its kind to display biphasic kinetics.<ref name="residue paper"/> FadD13 first activates the fatty acid through a reaction with ATP to form an acyl adenylate intermediate and subsequently releases a pyrophosphate. Following a conformational change of the enzyme upon the binding of ATP, coenzyme A is able to bind to its active site and react with the acyl adenylate intermediate forming the [http://en.wikipedia.org/wiki/Acyl-CoA acyl CoA] product (Figure 2). These activated fatty acyl-CoA thioesters have then been demonstrated to be important for the synthesis of triacyglycerols and phospholipids in the membrane of ''Mycobacterium tuberculosis''. <ref name="residue paper"/>