Sandbox Reserved 1066: Difference between revisions
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''Mycobacterium tuberculosis'' ''(M.tb)'' is the causative agent involved in the disease '''tuberculosis'''. Tuberculosis is a growing global health concern that has been intensified due to the increase in HIV infections along with the increase in multi-drug resistance strains of ''(M. tb)'' <ref name="molecular studies">PMID: 20454815</ref>. Most of the drug resistance has evolved due to the intensive nature of the treatment for tuberculosis, which often goes incomplete thus resulting in drug resistant strains; therefore, the importance in identifying characteristics and residues to be exploited for new drug targets is pivotal <ref name="molecular studies"/>. | ''Mycobacterium tuberculosis'' ''(M.tb)'' is the causative agent involved in the disease '''tuberculosis'''. Tuberculosis is a growing global health concern that has been intensified due to the increase in HIV infections along with the increase in multi-drug resistance strains of ''(M. tb)'' <ref name="molecular studies">PMID: 20454815</ref>. Most of the drug resistance has evolved due to the intensive nature of the treatment for tuberculosis, which often goes incomplete thus resulting in drug resistant strains; therefore, the importance in identifying characteristics and residues to be exploited for new drug targets is pivotal <ref name="molecular studies"/>. | ||
The cell wall of ''(M. tb)'' is known to be composed and synthesized from a distinct variety of lipids, most notably mycolic acids, which are known to play a crucial role in pathogenesis of ''(M. tb)'' <ref name="molecular studies"/>. | The cell wall of ''(M. tb)'' is known to be composed and synthesized from a distinct variety of lipids, most notably mycolic acids, which are known to play a crucial role in the pathogenesis of ''(M. tb)'' <ref name="molecular studies"/>. | ||
== Relevance of key mutational studies to the understanding and development of new inhibitors for FadD13 == | == Relevance of key mutational studies to the understanding and development of new inhibitors for FadD13 == | ||
