Sandbox Reserved 1058: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Perry Rabin (talk | contribs) No edit summary |
Perry Rabin (talk | contribs) No edit summary |
||
| Line 42: | Line 42: | ||
===Inhibitors=== | ===Inhibitors=== | ||
Due to the increased usefulness of this enzyme in propagating ''M. tuberculosis'' infections, specific inhibitors are being looked into as possible therapeutic targets for isocitrate lyase. Two such inhibitors that have already been identified are bromopyruvate and nitropropionate. Unfortunately, these molecules are non-specific and would also inhibit other enzymes essential for host function. <ref name="dunn"> Dunn, M.; Ramírez-Trujillo, J.; Hernández-Lucas, I.; Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis. ''Microbiology''. '''2009'''. ''155'':3166-3175. doi:10.1099/mic.0.030858-0. </ref> More research is needed to identify inhibitors that selectively target enzymes in the glyoxylate cycle. | Due to the increased usefulness of this enzyme in propagating ''M. tuberculosis'' infections, specific inhibitors are being looked into as possible therapeutic targets for isocitrate lyase. Two such inhibitors that have already been identified are bromopyruvate and nitropropionate. Unfortunately, these molecules are non-specific and would also inhibit other enzymes essential for host function. <ref name="dunn"> Dunn, M.; Ramírez-Trujillo, J.; Hernández-Lucas, I.; Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis. ''Microbiology''. '''2009'''. ''155'':3166-3175. doi:10.1099/mic.0.030858-0. </ref> More research is needed to identify inhibitors that selectively target enzymes in the glyoxylate cycle. | ||
==3D Structures of Isocitrate Lyase== | |||
[http://www.rcsb.org/pdb/explore/explore.do?structureId=1DQU 1DQU]from ''Aspergillus nidulans''. | |||
