Sandbox Reserved 1061: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 34: | Line 34: | ||
== Relevance == | == Relevance == | ||
Like most NrdHs, MtNrdH is similar in sequence to glutaredoxins, but structurally similar to thioredoxins. MtNrdH also accepts electrons from thiordoxin reductase, a characteristic of thiordoxins, but not glutaredoxins. | Like most NrdHs, MtNrdH is similar in sequence to glutaredoxins, but structurally similar to thioredoxins. MtNrdH also accepts electrons from thiordoxin reductase, a characteristic of thiordoxins, but not glutaredoxins. [[Image:Image-Super imposed molecules.png|thumb|left|Structural comparison of NrdHs with "thioredoxin folds": ''E. Coli'' NrdH (green), ''C. ammoniagenes'' NrdH (blue), ''M. tuberculosis'' NrdH (red)]] | ||
Similar structures of NrdH have been isolated in other primitive species including ''E. coli'', ''S. pyogenes'', ''S. typhimurium'', ''D. deserti'', ''S. flexneri 2457T'', and ''S. dysenteriae''. In higher order multi-cellular organisms, however the NrdH protein is replaced by more complex glutaredoxins or theirodoxins. This observation leads some to speculate that NrdH is one of the very first ancestors in the ribonucleotide reduction pathway. If this is true, NrdH can be seen as a critical protein that allowed for the development of DNA-based life since deoxyribonucleotides could not have existed without the ribonucleotide reduction pathway. A better understanding of the evolutionary timeline of NrdH and similar proteins could shed greater light onto the RNA Wold Hypothesis, specifically describing the time frame of emergence of DNA based life. | Similar structures of NrdH have been isolated in other primitive species including ''E. coli'', ''S. pyogenes'', ''S. typhimurium'', ''D. deserti'', ''S. flexneri 2457T'', and ''S. dysenteriae''. In higher order multi-cellular organisms, however the NrdH protein is replaced by more complex glutaredoxins or theirodoxins. This observation leads some to speculate that NrdH is one of the very first ancestors in the ribonucleotide reduction pathway. If this is true, NrdH can be seen as a critical protein that allowed for the development of DNA-based life since deoxyribonucleotides could not have existed without the ribonucleotide reduction pathway. A better understanding of the evolutionary timeline of NrdH and similar proteins could shed greater light onto the RNA Wold Hypothesis, specifically describing the time frame of emergence of DNA based life. | ||
