Sandbox Reserved 1061: Difference between revisions
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<StructureSection load='4hs1' size='300' side='right' caption='Micobacterium tuberculosis NrdH' scene=''> | <StructureSection load='4hs1' size='300' side='right' caption='Micobacterium tuberculosis NrdH' scene=''> | ||
== Overview == | == Overview == | ||
''Mycobacterium tuberculosis'' NrdH is a small glutaredoxin-like protein involved in the electron transport chain in ribonucleotide reduction.<ref>Swastik, Phulera and Mande, Shekhar C. (2013) The Crystal Structure of Mycobacterium tuberculosis NrdH at 0.87Å Suggests a Possible Mode of Its Activity. Biochemistry 52, 4056-4065.</ref> | ''Mycobacterium tuberculosis'' NrdH is a small glutaredoxin-like protein involved in the electron transport chain in ribonucleotide reduction. Therefore, it is extremely important in DNA production and replication because it helps supply cells with deoxyribonucleotides. Reduction of MtNrdH results in the breaking of an internal disulfide bond at the active site, allowing it to accept electrons and pass them on downstream <ref>Swastik, Phulera and Mande, Shekhar C. (2013) The Crystal Structure of Mycobacterium tuberculosis NrdH at 0.87Å Suggests a Possible Mode of Its Activity. Biochemistry 52, 4056-4065.</ref> | ||
== Background == | == Background == | ||
