1of5: Difference between revisions
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==Overview== | ==Overview== | ||
The association between Mtr2 and Mex67 is essential for the nuclear export, of bulk messenger RNA in yeast. In metazoans, the analogous function is, carried out by the TAP-p15 heterodimer. Whereas Mex67 and TAP are highly, conserved proteins, their binding partners, Mtr2 and p15, share no, sequence similarity, but are nevertheless functionally homologous. Here, we report the 2.8-A resolution crystal structure of Mtr2 in complex with, the NTF2-like domain of Mex67. Mtr2 is a novel member of the NTF2-like, family and interacts with Mex67, forming a complex with a similar, structural architecture to that of TAP-p15. Mtr2 fulfils an analogous, function to that of human p15 in maintaining the structural integrity of, the heterodimer. In addition, Mtr2 presents a long internal loop, which, . | The association between Mtr2 and Mex67 is essential for the nuclear export, of bulk messenger RNA in yeast. In metazoans, the analogous function is, carried out by the TAP-p15 heterodimer. Whereas Mex67 and TAP are highly, conserved proteins, their binding partners, Mtr2 and p15, share no, sequence similarity, but are nevertheless functionally homologous. Here, we report the 2.8-A resolution crystal structure of Mtr2 in complex with, the NTF2-like domain of Mex67. Mtr2 is a novel member of the NTF2-like, family and interacts with Mex67, forming a complex with a similar, structural architecture to that of TAP-p15. Mtr2 fulfils an analogous, function to that of human p15 in maintaining the structural integrity of, the heterodimer. In addition, Mtr2 presents a long internal loop, which, contains residues that affect the export of the large ribosomal subunit. | ||
==About this Structure== | ==About this Structure== | ||
1OF5 is a | 1OF5 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with HG as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OF5 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: transport]] | [[Category: transport]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:18:34 2007'' | ||
