2uzg: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2uzg.jpg|left|200px]] | [[Image:2uzg.jpg|left|200px]] | ||
'''ZF-UBP DOMAIN OF VDU1''' | {{Structure | ||
|PDB= 2uzg |SIZE=350|CAPTION= <scene name='initialview01'>2uzg</scene> | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''ZF-UBP DOMAIN OF VDU1''' | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
2UZG is a [ | 2UZG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZG OCA]. | ||
==Reference== | ==Reference== | ||
The solution structure of the ZnF UBP domain of USP33/VDU1., Allen MD, Bycroft M, Protein Sci. 2007 Sep;16(9):2072-5. PMID:[http:// | The solution structure of the ZnF UBP domain of USP33/VDU1., Allen MD, Bycroft M, Protein Sci. 2007 Sep;16(9):2072-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17766394 17766394] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| Line 29: | Line 38: | ||
[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:41:34 2008'' | ||
Revision as of 16:41, 20 March 2008
| |||||||||||||
| 2uzg | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | ZN | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
ZF-UBP DOMAIN OF VDU1
Overview
USP33/VDU1 is a deubiquitinating enzyme that binds to the von Hippel-Lindau tumor suppressor protein. It also regulates thyroid hormone activation by deubiquitinating type 2 iodothyronine deiodinase. USP33/VDU1 contains a ZF UBP domain, a protein module found in many proteins in the ubiquitin-proteasome system. Several ZF UBP domains have been shown to bind ubiquitin, and a structure of a complex of the ZF UBP domain of isoT/USP5 and ubiquitin is available. In the present work, the solution structure of the ZF UBP domain of USP33/VDU1 has been determined by NMR spectroscopy. The structure differs from that of the USP5 domain, which contains only one of the three Zn ions present in the USP33/VDU1 structure. The USP33/VDU1 ZnF UBP domain does not bind to ubiquitin.
About this Structure
2UZG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The solution structure of the ZnF UBP domain of USP33/VDU1., Allen MD, Bycroft M, Protein Sci. 2007 Sep;16(9):2072-5. PMID:17766394
Page seeded by OCA on Thu Mar 20 18:41:34 2008
