2uzh: Difference between revisions

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[[Image:2uzh.jpg|left|200px]]<br /><applet load="2uzh" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2uzh.jpg|left|200px]]
caption="2uzh, resolution 2.20&Aring;" />
 
'''MYCOBACTERIUM SMEGMATIS 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE (ISPF)'''<br />
{{Structure
|PDB= 2uzh |SIZE=350|CAPTION= <scene name='initialview01'>2uzh</scene>, resolution 2.20&Aring;
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Cdf+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Chain+B'>AC3</scene>, <scene name='pdbsite=AC4:Cdf+Binding+Site+For+Chain+B'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Chain+C'>AC5</scene>, <scene name='pdbsite=AC6:Cdf+Binding+Site+For+Chain+C'>AC6</scene>, <scene name='pdbsite=AC7:Edo+Binding+Site+For+Chain+C'>AC7</scene>, <scene name='pdbsite=AC8:Edo+Binding+Site+For+Chain+A'>AC8</scene>, <scene name='pdbsite=AC9:Ipe+Binding+Site+For+Chain+B'>AC9</scene>, <scene name='pdbsite=BC1:Gol+Binding+Site+For+Chain+C'>BC1</scene>, <scene name='pdbsite=BC2:Gol+Binding+Site+For+Chain+A'>BC2</scene>, <scene name='pdbsite=BC3:Gol+Binding+Site+For+Chain+B'>BC3</scene>, <scene name='pdbsite=BC4:Act+Binding+Site+For+Chain+C'>BC4</scene>, <scene name='pdbsite=BC5:Peg+Binding+Site+For+Chain+B'>BC5</scene> and <scene name='pdbsite=BC6:Peg+Binding+Site+For+Chain+B'>BC6</scene>
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CDF:CYTIDINE-5'-DIPHOSPHATE'>CDF</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IPE:3-METHYLBUT-3-ENYL+TRIHYDROGEN+DIPHOSPHATE'>IPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> and <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12]
|GENE=
}}
 
'''MYCOBACTERIUM SMEGMATIS 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE (ISPF)'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2UZH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=CDF:'>CDF</scene>, <scene name='pdbligand=EDO:'>EDO</scene>, <scene name='pdbligand=IPE:'>IPE</scene>, <scene name='pdbligand=GOL:'>GOL</scene> and <scene name='pdbligand=PEG:'>PEG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/2-C-methyl-D-erythritol_2,4-cyclodiphosphate_synthase 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.12 4.6.1.12] Known structural/functional Sites: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Cdf+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Chain+B'>AC3</scene>, <scene name='pdbsite=AC4:Cdf+Binding+Site+For+Chain+B'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Chain+C'>AC5</scene>, <scene name='pdbsite=AC6:Cdf+Binding+Site+For+Chain+C'>AC6</scene>, <scene name='pdbsite=AC7:Edo+Binding+Site+For+Chain+C'>AC7</scene>, <scene name='pdbsite=AC8:Edo+Binding+Site+For+Chain+A'>AC8</scene>, <scene name='pdbsite=AC9:Ipe+Binding+Site+For+Chain+B'>AC9</scene>, <scene name='pdbsite=BC1:Gol+Binding+Site+For+Chain+C'>BC1</scene>, <scene name='pdbsite=BC2:Gol+Binding+Site+For+Chain+A'>BC2</scene>, <scene name='pdbsite=BC3:Gol+Binding+Site+For+Chain+B'>BC3</scene>, <scene name='pdbsite=BC4:Act+Binding+Site+For+Chain+C'>BC4</scene>, <scene name='pdbsite=BC5:Peg+Binding+Site+For+Chain+B'>BC5</scene> and <scene name='pdbsite=BC6:Peg+Binding+Site+For+Chain+B'>BC6</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZH OCA].  
2UZH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UZH OCA].  


==Reference==
==Reference==
The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery., Buetow L, Brown AC, Parish T, Hunter WN, BMC Struct Biol. 2007 Oct 23;7:68. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17956607 17956607]
The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery., Buetow L, Brown AC, Parish T, Hunter WN, BMC Struct Biol. 2007 Oct 23;7:68. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17956607 17956607]
[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
[[Category: Mycobacterium smegmatis]]
[[Category: Mycobacterium smegmatis]]
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[[Category: non-mevalonate pathway of isoprenoid biosynthesis]]
[[Category: non-mevalonate pathway of isoprenoid biosynthesis]]


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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:41:35 2008''
Retrieved from "https://proteopedia.org/2uzh"