2v2d: Difference between revisions

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New page: left|200px<br /><applet load="2v2d" size="350" color="white" frame="true" align="right" spinBox="true" caption="2v2d, resolution 2.30Å" /> '''THE A178L MUTATION I...
 
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[[Image:2v2d.jpg|left|200px]]<br /><applet load="2v2d" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2v2d.jpg|left|200px]]
caption="2v2d, resolution 2.30&Aring;" />
 
'''THE A178L MUTATION IN THE C-TERMINAL HINGE OF THE FLEXIBLE LOOP-6 OF TRIOSEPHOSPHATE ISOMERASE (TIM) INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC TIM'''<br />
{{Structure
|PDB= 2v2d |SIZE=350|CAPTION= <scene name='initialview01'>2v2d</scene>, resolution 2.30&Aring;
|SITE= <scene name='pdbsite=AC1:Po4+Binding+Site+For+Chain+A'>AC1</scene>
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1]
|GENE=
}}
 
'''THE A178L MUTATION IN THE C-TERMINAL HINGE OF THE FLEXIBLE LOOP-6 OF TRIOSEPHOSPHATE ISOMERASE (TIM) INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC TIM'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2V2D is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] Known structural/functional Site: <scene name='pdbsite=AC1:Po4+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2D OCA].  
2V2D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2D OCA].  


==Reference==
==Reference==
Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM., Alahuhta M, Casteleijn MG, Neubauer P, Wierenga RK, Acta Crystallogr D Biol Crystallogr. 2008 Feb;64(Pt 2):178-88. Epub 2008, Jan 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18219118 18219118]
Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM., Alahuhta M, Casteleijn MG, Neubauer P, Wierenga RK, Acta Crystallogr D Biol Crystallogr. 2008 Feb;64(Pt 2):178-88. Epub 2008, Jan 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18219118 18219118]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Triose-phosphate isomerase]]
[[Category: Triose-phosphate isomerase]]
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[[Category: triosephosphate isomerase]]
[[Category: triosephosphate isomerase]]


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