4o9h: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,332,843 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''
==Structure of Interleukin-6 in complex with a Camelid Fab fragment==
 
<StructureSection load='4o9h' size='340' side='right' caption='[[4o9h]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
The entry 4o9h is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4o9h]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O9H FirstGlance]. <br>
Authors: Klarenbeek, A., Blanchetot, C., Schragel, G., Sadi, A.S., Ongenae, N., Hemrika, W., Wijdenes, J., Spinelli, S., Desmyter, A., Cambillau, C., Hultberg, A., Kretz-rommel, A., Dreier, T., De haard, H.J.W., Roovers, R.C.
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o9h RCSB], [http://www.ebi.ac.uk/pdbsum/4o9h PDBsum]</span></td></tr>
 
</table>
Description: Structure of Interleukin-6 in complex with a Camelid Fab fragment
== Disease ==
[[Category: Unreleased Structures]]
[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.  Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
[[Category: Klarenbeek, A]]
== Function ==
[[http://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN]] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
__TOC__
</StructureSection>
[[Category: Blanchetot, C]]
[[Category: Cambillau, C]]
[[Category: Cambillau, C]]
[[Category: Wijdenes, J]]
[[Category: Desmyter, A]]
[[Category: Dreier, T]]
[[Category: Dreier, T]]
[[Category: Kretz-Rommel, A]]
[[Category: Hemrika, W]]
[[Category: Hultberg, A]]
[[Category: Hultberg, A]]
[[Category: Roovers, R.C]]
[[Category: Klarenbeek, A]]
[[Category: De Haard, H.J.W]]
[[Category: Kretz-rommel, A]]
[[Category: Sadi, A.S]]
[[Category: Hemrika, W]]
[[Category: Spinelli, S]]
[[Category: Ongenae, N]]
[[Category: Ongenae, N]]
[[Category: Blanchetot, C]]
[[Category: Roovers, R C]]
[[Category: Desmyter, A]]
[[Category: Sadi, A S]]
[[Category: Schragel, G]]
[[Category: Schragel, G]]
[[Category: Spinelli, S]]
[[Category: Wijdenes, J]]
[[Category: Haard, H J.W De]]
[[Category: Fab: all beta protein]]
[[Category: Il6: all alpha protein]]
[[Category: Immune system]]
Retrieved from "https://proteopedia.org/4o9h"