4omk: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of SPF bound to squalene==

~~The entry~~ 4omk is ~~ON HOLD until Apr 12 2016~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4omk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OMK OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OMK FirstGlance].

~~Authors~~: ~~Christen~~, M., ~~Marcaida~~, M.J., ~~Lamprakis, C~~.~~, Cascella, M~~.~~, Stocker, A~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SQL:(6E,10E,14E,18E)-2,6,10,15,19,23-HEXAMETHYLTETRACOSA-2,6,10,14,18,22-HEXAENE'>SQL</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[1olm|1olm]], [[1o6u|1o6u]], [[4omj|4omj]]</td></tr>

~~Description~~: ~~Crystal~~ structure of ~~SPF bound~~ to ~~squalene~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4omk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4omk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4omk RCSB], [http://www.ebi.ac.uk/pdbsum/4omk PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/S14L2_HUMAN S14L2_HUMAN]] Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.

__TOC__

</StructureSection>

[[Category: Cascella, M]]

[[Category: Christen, M]]

[[Category: Lamprakis, C]]

[[Category: Marcaida, M J]]

[[Category: Stocker, A]]

[[Category: ~~Lamprakis, C~~]]

[[Category: 3-oxidosqualene]]

[[Category: ~~Marcaida, M.J~~]]

[[Category: Cholesterol synthesis]]

[[Category: ~~Christen, M~~]]

[[Category: Cral-trio domain]]

[[Category: ~~Cascella, M~~]]

[[Category: Hydrophobic ligand transporter]]

[[Category: Sec14-like]]

[[Category: Squalene]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of SPF bound to squalene==
+<StructureSection load='4omk' size='340' side='right' caption='[[4omk]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-The entry 4omk is ON HOLD  until Apr 12 2016
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4omk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OMK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OMK FirstGlance]. <br>
-Authors: Christen, M., Marcaida, M.J., Lamprakis, C., Cascella, M., Stocker, A.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SQL:(6E,10E,14E,18E)-2,6,10,15,19,23-HEXAMETHYLTETRACOSA-2,6,10,14,18,22-HEXAENE'>SQL</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1olm|1olm]], [[1o6u|1o6u]], [[4omj|4omj]]</td></tr>
-Description: Crystal structure of SPF bound to squalene
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4omk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4omk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4omk RCSB], [http://www.ebi.ac.uk/pdbsum/4omk PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/S14L2_HUMAN S14L2_HUMAN]] Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
+__TOC__
+</StructureSection>
+[[Category: Cascella, M]]
+[[Category: Christen, M]]
+[[Category: Lamprakis, C]]
+[[Category: Marcaida, M J]]
 [[Category: Stocker, A]]
-[[Category: Lamprakis, C]]
+[[Category: 3-oxidosqualene]]
-[[Category: Marcaida, M.J]]
+[[Category: Cholesterol synthesis]]
-[[Category: Christen, M]]
+[[Category: Cral-trio domain]]
-[[Category: Cascella, M]]
+[[Category: Hydrophobic ligand transporter]]
+[[Category: Sec14-like]]
+[[Category: Squalene]]
+[[Category: Transport protein]]