2v2h: Difference between revisions

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'''THE A178L MUTATION IN THE C-TERMINAL HINGE OF THE FLEXIBLE LOOP-6 OF TRIOSEPHOSPHATE ISOMERASE (TIM) INDUCES A MORE CLOSED CONFORMATION OF THIS HINGE REGION IN DIMERIC AND MONOMERIC TIM'''<br />

2V2H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei] with <scene name='pdbligand=PGA:'>PGA</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Triose-phosphate_isomerase Triose-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.1 5.3.1.1] Known structural/functional Sites: <scene name='pdbsite=AC1:Pga+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Pga+Binding+Site+For+Chain+B'>AC2</scene>, <scene name='pdbsite=AC3:Pga+Binding+Site+For+Chain+C'>AC3</scene>, <scene name='pdbsite=AC4:Cl+Binding+Site+For+Chain+C'>AC4</scene>, <scene name='pdbsite=AC5:Cl+Binding+Site+For+Chain+B'>AC5</scene> and <scene name='pdbsite=AC6:Cl+Binding+Site+For+Chain+A'>AC6</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V2H OCA].  

Structural studies show that the A178L mutation in the C-terminal hinge of the catalytic loop-6 of triosephosphate isomerase (TIM) induces a closed-like conformation in dimeric and monomeric TIM., Alahuhta M, Casteleijn MG, Neubauer P, Wierenga RK, Acta Crystallogr D Biol Crystallogr. 2008 Feb;64(Pt 2):178-88. Epub 2008, Jan 16. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18219118 18219118]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:52:49 2008''