Sandbox Reserved 1051: Difference between revisions

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	===Cysteine 209===		===Cysteine 209===
	<scene name='69/694218/Cysteine_209/1'>Cysteine 209</scene> is located near the <scene name='69/697503/Active_site/2'>Ag85C active site</scene>, but is not directly involved in the enzyme mechanism. Recent studies suggest that this residue plays a significant role in the deactivation of Ag85C, using a mechanism not previously considered for these enzymes. Any mutation or modification to the Cys209 residue results in the relaxation of the otherwise kicked α-helix 9, which disrupts the hydrogen bonding network within the catalytic triad of the enzyme and inactivates Ag85C.<ref name="Favrot"/>		<scene name='69/694218/Cysteine_209/2'>Cysteine 209</scene> is located near the <scene name='69/697503/Active_site/2'>Ag85C active site</scene>, but is not directly involved in the enzyme mechanism. Recent studies suggest that this residue plays a significant role in the deactivation of Ag85C, using a mechanism not previously considered for these enzymes. Any mutation or modification to the Cys209 residue results in the relaxation of the otherwise kicked α-helix 9, which disrupts the hydrogen bonding network within the catalytic triad of the enzyme and inactivates Ag85C.<ref name="Favrot"/>

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