Sandbox Reserved 1061: Difference between revisions
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[http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis ''Mycobacterium tuberculosis'']resides in the lungs of a host and upon becoming active, results in a Tuberculosis infection (TB) and the ensuing symptoms of chest pain, weakness, and intense coughing. Left untreated and unmanaged, TB can lead to death (1.5 million in 2013).<ref name="WHO">"Tuberculosis." Media Centre. World Health Organization, Web. 16 Mar. 2015. Media Centre. <http://www.who.int/mediacentre/factsheets/fs104/en/>.</ref> The disease has a high co-morbidity with HIV/AIDS due to its immunocompromising tendencies. TB is one of the most heavily studied diseases today. With over 9 million infections worldwide per year, the necessity for antimicrobial agents to combat emerging multi-drug resistant strands is imperative.<ref name="WHO" /> | [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis ''Mycobacterium tuberculosis'']resides in the lungs of a host and upon becoming active, results in a Tuberculosis infection (TB) and the ensuing symptoms of chest pain, weakness, and intense coughing. Left untreated and unmanaged, TB can lead to death (1.5 million in 2013).<ref name="WHO">"Tuberculosis." Media Centre. World Health Organization, Web. 16 Mar. 2015. Media Centre. <http://www.who.int/mediacentre/factsheets/fs104/en/>.</ref> The disease has a high co-morbidity with HIV/AIDS due to its immunocompromising tendencies. TB is one of the most heavily studied diseases today. With over 9 million infections worldwide per year, the necessity for antimicrobial agents to combat emerging multi-drug resistant strands is imperative.<ref name="WHO" /> | ||
<StructureSection> | |||
== Structure == | == Structure == | ||
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MtNrdH can serve as a potential drug target to treat tuberculosis. The genes encoding NrdE and NrdF2, a cofactor in class 1b ribonucleotide reduction, are essential for growth of M. tuberculosis in vitro.<ref>Swastik, Phulera and Mande, Shekhar C. (2013) 4057.</ref> This suggest that M. tuberculosis relies solely on class Ib ribonucleotide reduction. If that is the case, NrdH may be an essential gene as well. Since NrdH is not found in humans, a drug that targets NrdH would be able to damage M. tuberculosis cells without hurting the human host. | MtNrdH can serve as a potential drug target to treat tuberculosis. The genes encoding NrdE and NrdF2, a cofactor in class 1b ribonucleotide reduction, are essential for growth of M. tuberculosis in vitro.<ref>Swastik, Phulera and Mande, Shekhar C. (2013) 4057.</ref> This suggest that M. tuberculosis relies solely on class Ib ribonucleotide reduction. If that is the case, NrdH may be an essential gene as well. Since NrdH is not found in humans, a drug that targets NrdH would be able to damage M. tuberculosis cells without hurting the human host. | ||
</StructureSection> | |||
== References == | == References == | ||
{{reflist}} | {{reflist}} | ||
