2vcg: Difference between revisions

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[[Image:2vcg.jpg|left|200px]]<br /><applet load="2vcg" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2vcg.jpg|left|200px]]
caption="2vcg, resolution 1.90&Aring;" />
 
'''CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17'''<br />
{{Structure
|PDB= 2vcg |SIZE=350|CAPTION= <scene name='initialview01'>2vcg</scene>, resolution 1.90&Aring;
|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+D'>AC1</scene>, <scene name='pdbsite=AC2:Gol+Binding+Site+For+Chain+C'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Chain+B'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Chain+C'>AC5</scene>, <scene name='pdbsite=AC6:Zn+Binding+Site+For+Chain+D'>AC6</scene>, <scene name='pdbsite=AC7:Zn+Binding+Site+For+Chain+D'>AC7</scene>, <scene name='pdbsite=AC8:K+Binding+Site+For+Chain+A'>AC8</scene>, <scene name='pdbsite=AC9:K+Binding+Site+For+Chain+B'>AC9</scene>, <scene name='pdbsite=BC1:K+Binding+Site+For+Chain+C'>BC1</scene>, <scene name='pdbsite=BC2:K+Binding+Site+For+Chain+D'>BC2</scene>, <scene name='pdbsite=BC3:K+Binding+Site+For+Chain+A'>BC3</scene>, <scene name='pdbsite=BC4:K+Binding+Site+For+Chain+B'>BC4</scene>, <scene name='pdbsite=BC5:K+Binding+Site+For+Chain+C'>BC5</scene>, <scene name='pdbsite=BC6:K+Binding+Site+For+Chain+D'>BC6</scene>, <scene name='pdbsite=BC7:S17+Binding+Site+For+Chain+D'>BC7</scene>, <scene name='pdbsite=BC8:S17+Binding+Site+For+Chain+C'>BC8</scene>, <scene name='pdbsite=BC9:S17+Binding+Site+For+Chain+A'>BC9</scene>, <scene name='pdbsite=CC1:S17+Binding+Site+For+Chain+B'>CC1</scene> and <scene name='pdbsite=CC2:Cl+Binding+Site+For+Chain+D'>CC2</scene>
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=S17:'>S17</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
|ACTIVITY=
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF A HDAC-LIKE PROTEIN HDAH FROM BORDETELLA SP. WITH THE BOUND INHIBITOR ST-17'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2VCG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=K:'>K</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=S17:'>S17</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+D'>AC1</scene>, <scene name='pdbsite=AC2:Gol+Binding+Site+For+Chain+C'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Chain+B'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Chain+C'>AC5</scene>, <scene name='pdbsite=AC6:Zn+Binding+Site+For+Chain+D'>AC6</scene>, <scene name='pdbsite=AC7:Zn+Binding+Site+For+Chain+D'>AC7</scene>, <scene name='pdbsite=AC8:K+Binding+Site+For+Chain+A'>AC8</scene>, <scene name='pdbsite=AC9:K+Binding+Site+For+Chain+B'>AC9</scene>, <scene name='pdbsite=BC1:K+Binding+Site+For+Chain+C'>BC1</scene>, <scene name='pdbsite=BC2:K+Binding+Site+For+Chain+D'>BC2</scene>, <scene name='pdbsite=BC3:K+Binding+Site+For+Chain+A'>BC3</scene>, <scene name='pdbsite=BC4:K+Binding+Site+For+Chain+B'>BC4</scene>, <scene name='pdbsite=BC5:K+Binding+Site+For+Chain+C'>BC5</scene>, <scene name='pdbsite=BC6:K+Binding+Site+For+Chain+D'>BC6</scene>, <scene name='pdbsite=BC7:S17+Binding+Site+For+Chain+D'>BC7</scene>, <scene name='pdbsite=BC8:S17+Binding+Site+For+Chain+C'>BC8</scene>, <scene name='pdbsite=BC9:S17+Binding+Site+For+Chain+A'>BC9</scene>, <scene name='pdbsite=CC1:S17+Binding+Site+For+Chain+B'>CC1</scene> and <scene name='pdbsite=CC2:Cl+Binding+Site+For+Chain+D'>CC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA].  
2VCG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Alcaligenes_sp. Alcaligenes sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VCG OCA].  


==Reference==
==Reference==
Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)., Schafer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M, Bioorg Med Chem. 2008 Feb 15;16(4):2011-33. Epub 2007 Nov 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18054239 18054239]
Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)., Schafer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M, Bioorg Med Chem. 2008 Feb 15;16(4):2011-33. Epub 2007 Nov 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18054239 18054239]
[[Category: Alcaligenes sp.]]
[[Category: Alcaligenes sp.]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: inhibitor]]
[[Category: inhibitor]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:55:04 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:45:25 2008''
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