4xq7: Difference between revisions
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''' | ==The crystal structure of the OAS-like domain (OLD) of human OASL== | ||
<StructureSection load='4xq7' size='340' side='right' caption='[[4xq7]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4xq7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XQ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XQ7 FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xq7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xq7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xq7 RCSB], [http://www.ebi.ac.uk/pdbsum/4xq7 PDBsum]</span></td></tr> | |||
</table> | |||
[[Category: | == Function == | ||
[[Category: Gad, H | [[http://www.uniprot.org/uniprot/OASL_HUMAN OASL_HUMAN]] Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.<ref>PMID:9826176</ref> <ref>PMID:18931074</ref> <ref>PMID:20074559</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Andersen, L L]] | |||
[[Category: Gad, H H]] | |||
[[Category: Hartmann, R]] | |||
[[Category: Hornung, V]] | [[Category: Hornung, V]] | ||
[[Category: Ibsen, M | [[Category: Ibsen, M S]] | ||
[[Category: Julkunen, I]] | [[Category: Julkunen, I]] | ||
[[Category: | [[Category: Sarkar, S N]] | ||
[[Category: 2'-5' oligoadenylate synthetase]] | |||
[[Category: Oa]] | |||
[[Category: Oasl]] | |||
[[Category: Oligoadenylate synthetase]] | |||
[[Category: Oligoadenylate synthetase-like]] | |||
[[Category: Transferase]] | |||
Revision as of 12:54, 22 April 2015
The crystal structure of the OAS-like domain (OLD) of human OASL
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