2vgu: Difference between revisions

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[[Image:2vgu.jpg|left|200px]]<br /><applet load="2vgu" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2vgu.jpg|left|200px]]
caption="2vgu, resolution 1.80&Aring;" />
 
'''CRYSTAL STRUCTURE OF E53QBSSHMT WITH L-SERINE'''<br />
{{Structure
|PDB= 2vgu |SIZE=350|CAPTION= <scene name='initialview01'>2vgu</scene>, resolution 1.80&Aring;
|SITE= <scene name='pdbsite=AC1:Plp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:SER+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Mpd+Binding+Site+For+Chain+A'>AC3</scene> and <scene name='pdbsite=AC4:Po4+Binding+Site+For+Chain+A'>AC4</scene>
|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene> and <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1]
|GENE=
}}
 
'''CRYSTAL STRUCTURE OF E53QBSSHMT WITH L-SERINE'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2VGU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=SER:'>SER</scene> and <scene name='pdbligand=MPD:'>MPD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Glycine_hydroxymethyltransferase Glycine hydroxymethyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.1 2.1.2.1] Known structural/functional Sites: <scene name='pdbsite=AC1:Plp+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:SER+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Mpd+Binding+Site+For+Chain+A'>AC3</scene> and <scene name='pdbsite=AC4:Po4+Binding+Site+For+Chain+A'>AC4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VGU OCA].  
2VGU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VGU OCA].  


==Reference==
==Reference==
Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory., Rajaram V, Bhavani BS, Kaul P, Prakash V, Appaji Rao N, Savithri HS, Murthy MR, FEBS J. 2007 Aug;274(16):4148-60. Epub 2007 Jul 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17651438 17651438]
Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory., Rajaram V, Bhavani BS, Kaul P, Prakash V, Appaji Rao N, Savithri HS, Murthy MR, FEBS J. 2007 Aug;274(16):4148-60. Epub 2007 Jul 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17651438 17651438]
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Glycine hydroxymethyltransferase]]
[[Category: Glycine hydroxymethyltransferase]]
Line 27: Line 36:
[[Category: enzyme memory]]
[[Category: enzyme memory]]
[[Category: one-carbon metabolism]]
[[Category: one-carbon metabolism]]
[[Category: plp-dependent enzymes]]
[[Category: plp-dependent enzyme]]
[[Category: pyridoxal phosphate]]
[[Category: pyridoxal phosphate]]
[[Category: shmt]]
[[Category: shmt]]
[[Category: transferase]]
[[Category: transferase]]


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