2vj8: Difference between revisions

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[[Image:2vj8.jpg|left|200px]]<br /><applet load="2vj8" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2vj8.jpg|left|200px]]
caption="2vj8, resolution 1.8&Aring;" />
 
'''COMPLEX OF HUMAN LEUKOTRIENE A4 HYDROLASE WITH A HYDROXAMIC ACID INHIBITOR'''<br />
{{Structure
|PDB= 2vj8 |SIZE=350|CAPTION= <scene name='initialview01'>2vj8</scene>, resolution 1.8&Aring;
|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Yb+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Yb+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Yb+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:Imd+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Act+Binding+Site+For+Chain+A'>AC6</scene> and <scene name='pdbsite=AC7:Ha2+Binding+Site+For+Chain+A'>AC7</scene>
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene> and <scene name='pdbligand=HA2:6-[{(2S)-2-AMINO-3-[4-(BENZYLOXY)PHENYL]PROPYL}(HYDROXY)AMINO]-6-OXOHEXANOIC ACID)'>HA2</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6]
|GENE=
}}
 
'''COMPLEX OF HUMAN LEUKOTRIENE A4 HYDROLASE WITH A HYDROXAMIC ACID INHIBITOR'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2VJ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=YB:'>YB</scene>, <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=IMD:'>IMD</scene> and <scene name='pdbligand=HA2:'>HA2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] Known structural/functional Sites: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:Yb+Binding+Site+For+Chain+A'>AC2</scene>, <scene name='pdbsite=AC3:Yb+Binding+Site+For+Chain+A'>AC3</scene>, <scene name='pdbsite=AC4:Yb+Binding+Site+For+Chain+A'>AC4</scene>, <scene name='pdbsite=AC5:Imd+Binding+Site+For+Chain+A'>AC5</scene>, <scene name='pdbsite=AC6:Act+Binding+Site+For+Chain+A'>AC6</scene> and <scene name='pdbsite=AC7:Ha2+Binding+Site+For+Chain+A'>AC7</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ8 OCA].  
2VJ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VJ8 OCA].  


==Reference==
==Reference==
Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors., Thunnissen MM, Andersson B, Samuelsson B, Wong CH, Haeggstrom JZ, FASEB J. 2002 Oct;16(12):1648-50. Epub 2002 Aug 7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12207002 12207002]
Crystal structures of leukotriene A4 hydrolase in complex with captopril and two competitive tight-binding inhibitors., Thunnissen MM, Andersson B, Samuelsson B, Wong CH, Haeggstrom JZ, FASEB J. 2002 Oct;16(12):1648-50. Epub 2002 Aug 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12207002 12207002]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Leukotriene-A(4) hydrolase]]
[[Category: Leukotriene-A(4) hydrolase]]
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[[Category: zinc]]
[[Category: zinc]]


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