Lactoperoxidase

Lactoperoxidase (LPO) catalyzes the oxidation of thiocyanate, bromide and iodide using hydrogen peroxide. The short-lived oxidized intermediates of the reaction serve as potent bactericidal agents. LPO is used as an antimicrobial agent in milk and its products, in cosmetics, toothpaste and ophthalmic solutions. LPO is the second most abundant enzyme in milk. Heme is the cofactor of LPO. LPO contains a strongly-chelated calcium ion.

3D structures of lactoperoxidase

Updated on 03-May-2015

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• Lactoperoxidase binary complex
  • 2pt3 - bPLO + phosphate - bovine
    
  • 2nqx – bPLO + I
    
  • 2r5l – gLPO + I – goat
    
  • 3nak – gLPO + formate
    
  • 4ig5, 4qyq – gLPO + antithyroid agent
    
• Lactoperoxidase ternary complex
  • 2gj1 – bLPO + carbonate + nitrate
    
  • 2ips, 3eri, 3gc1 – bLPO + SCN + I
    
  • 2qrb – bLPO + SCN + Cl
    
  • 3bxi – bLPO + SCN + nitrate
    
  • 4pnx - bPLO + bromomethane + I
    
  • 2pum – bPLO + catechol + I
    
  • 2gj1 – bLPO + carbonate + nitrate
    
  • 3krq – bLPO + amino-triazole + I
    
  • 2z5z – wbPLO + F + I – water buffalo
    
  • 2o86 – wbPLO + nitrate + I
    
  • 3erh - wbLPO + SCN + I
    
  • 2ojv – gPLO + CN + I
    
  • 3n8f - gLPO + SCN + nitrate
    
  • 3niu – gLPO + diethylene glycol + phosphate
    
  • 3rke - gPLO + inhibitor + I
    
  • 2ikc – sLPO + carbonate + formate – sheep
• Lactoperoxidase quaternary complex
  • 3gcj, 2qpk - bPLO + salicylhydroxamic acid + SCN + I
    
  • 3gck - bPLO + benzylhydroxamic acid + SCN + I
    
  • 3uba, 4gm7 - bPLO + hydroxycinnamic acid + SCN + I
    
  • 3gcl, 2qqt - bPLO + aspirin + SCN + I
    
  • 3i6n - bPLO + isoniazid + SCN + I
    
  • 4ksz - bPLO + cystein + SCN + I
    
  • 3nyh - bPLO + Br + Cl + SCN + I
    
  • 3ogw - bPLO + indomethacin + SCN + I
    
  • 3py4, 4gn6 - bPLO + paracetamol + SCN + I
    
  • 3q9k - bPLO + phenyliso-SCN + SCN + I
    
  • 3ql6 - bPLO + nitro-phenoxymethanesulfonanilide+ SCN + I
    
  • 3s4f, 4njb, 4nt3 - bPLO + pyridine derivative + SCN + I
    
  • 3r4x, 3tuw - bPLO + pyrazine derivative + SCN + I
    
  • 3r5o - bPLO + methoxyphenol + SCN + I
    
  • 3tgy - bPLO + ascorbate + SCN + I
    
  • 3v6q - bPLO + CO + SCN + I
    
  • 2gjm - wbPLO + carbonate + SCN + I
    
  • 3faq – wbLPO + CN + SCN + I
    
  • 3fnl - wbPLO + salicylhydroxamic acid + SCN + I
    
  • 2e9e – gPLO + nitrate + carbonate + SCN + CN
    
  • 2efb – gPLO + phosphate + carbonate + SCN + CN
    
  • 3qf1 - gPLO + piperazine + SCN + I
    
  • 4ljj - gPLO + acrylonitrile + SCN + I
    
  • 4msf, 4oek - gPLO + phenol derivative+ SCN + I
    
  • 2eha – gPLO + formate + carbonate + SCN
    
  • 3r55, 4n7a - gPLO + pyrazine derivative + SCN + I
    
  • 3sxv - gPLO + amitrole + SCN + I
    
  • 3r5q - sPLO +tetrahydrofuran + SCN + I
    
  • 4qjq - gPLO + octopamine + SCN + I
    
  • 4s0y - bLPO + butyl-triazole + SCN + I
    
  • 4y55 - wbLPO + rhodanide + SCN + I
    

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