5agq: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Solution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA genes==

~~The entry~~ 5agq is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5agq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AGQ FirstGlance]. <br>

~~Authors~~: ~~Anosova~~, I., ~~Melnik~~, S., ~~Tripsianes~~, K., ~~Kateb~~, F., ~~Grummt~~, I., ~~Sattler, M~~.

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5agq RCSB], [http://www.ebi.ac.uk/pdbsum/5agq PDBsum]</span></td></tr>

</table>

~~Description~~: ~~Solution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA genes~~

== Function ==

[[Category: ~~Unreleased Structures~~]]

[[http://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).

__TOC__

</StructureSection>

[[Category: Anosova, I]]

[[Category: Grummt, I]]

[[Category: Kateb, F]]

[[Category: Melnik, S]]

[[Category: Sattler, M]]

[[Category: Tripsianes, K]]

[[Category: ~~Sattler, M~~]]

[[Category: Epigenetic]]

[[Category: ~~Melnik, S~~]]

[[Category: Protein rna interaction]]

[[Category: ~~Grummt, I~~]]

[[Category: Rrna gene silencing]]

[[Category: ~~Anosova, I~~]]

[[Category: Tam domain]]

[[Category: Tip5/baz2a]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Solution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA genes==
+<StructureSection load='5agq' size='340' side='right' caption='[[5agq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-The entry 5agq is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5agq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AGQ FirstGlance]. <br>
-Authors: Anosova, I., Melnik, S., Tripsianes, K., Kateb, F., Grummt, I., Sattler, M.
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5agq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5agq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5agq RCSB], [http://www.ebi.ac.uk/pdbsum/5agq PDBsum]</span></td></tr>
+</table>
-Description: Solution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA genes
+== Function ==
-[[Category: Unreleased Structures]]
+[[http://www.uniprot.org/uniprot/BAZ2A_HUMAN BAZ2A_HUMAN]] Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Anosova, I]]
+[[Category: Grummt, I]]
 [[Category: Kateb, F]]
+[[Category: Melnik, S]]
+[[Category: Sattler, M]]
 [[Category: Tripsianes, K]]
-[[Category: Sattler, M]]
+[[Category: Epigenetic]]
-[[Category: Melnik, S]]
+[[Category: Protein rna interaction]]
-[[Category: Grummt, I]]
+[[Category: Rrna gene silencing]]
-[[Category: Anosova, I]]
+[[Category: Tam domain]]
+[[Category: Tip5/baz2a]]
+[[Category: Transcription]]