User:Wayne Decatur/Gal 4: Difference between revisions
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The DNA binding domain <scene name='70/701975/1d66_firstglance_zn_binding/2'>uses six Cys residues to coordinate the binding of two ions of zinc (Zn(II))</scene>. In the crystal structure [[1d66]], the zinc ions are represented by other members of the same group on the periodic table, the heavier cadmium ions. The Zn-binding motif lets the structure accomplish more with fewer amino acids, the metals lending an "economy of structure", arranging two small helices to recognize a specific DNA site. | The DNA binding domain <scene name='70/701975/1d66_firstglance_zn_binding/2'>uses six Cys residues to coordinate the binding of two ions of zinc (Zn(II))</scene>. (In the crystal structure [[1d66]], the zinc ions are actually represented by other members of the same group on the periodic table, the heavier cadmium ions.) The Zn-binding motif lets the structure accomplish more with fewer amino acids, the metals lending an "economy of structure", arranging two small helices to recognize a specific DNA site. | ||
The third large helix of each dimer subunit interacts with the other <scene name='70/701975/1d66_firstglance_slab/ | The third large helix of each dimer subunit interacts with the other <scene name='70/701975/1d66_firstglance_slab/3'>by arranging hydrophobic residues in the contact region</scene>. Note the abundance of gray residues in the central stem protruding from a site roughly the center of the DNA binding site. The dimer interface is more fully explored in a later publication with an expanded structure, see [[3coq]]. | ||
==Reference== | ==Reference== | ||
