4qbr: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of DNMT3a ADD domain G550D mutant bound to H3 peptide==

~~The entry~~ 4qbr is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4qbr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QBR OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QBR FirstGlance].

~~Authors~~: ~~Wang~~, H., Li, H.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4qbs|4qbs]], [[4qbq|4qbq]]</td></tr>

~~Description: Crystal structure of DNMT3a ADD domain G550D mutant bound to H3 peptide~~

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qbr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qbr RCSB], [http://www.ebi.ac.uk/pdbsum/4qbr PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DNM3A_HUMAN DNM3A_HUMAN]] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity).<ref>PMID:16357870</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Li, H]]

[[Category: Wang, H]]

[[Category: Histone binding]]

[[Category: Transferase]]

[[Category: Zinc finger]]

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-'''Unreleased structure'''
+==Crystal structure of DNMT3a ADD domain G550D mutant bound to H3 peptide==
+<StructureSection load='4qbr' size='340' side='right' caption='[[4qbr]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-The entry 4qbr is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4qbr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QBR FirstGlance]. <br>
-Authors: Wang, H., Li, H.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qbs|4qbs]], [[4qbq|4qbq]]</td></tr>
-Description: Crystal structure of DNMT3a ADD domain G550D mutant bound to H3 peptide
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_(cytosine-5-)-methyltransferase DNA (cytosine-5-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.37 2.1.1.37] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qbr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qbr RCSB], [http://www.ebi.ac.uk/pdbsum/4qbr PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DNM3A_HUMAN DNM3A_HUMAN]] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity).<ref>PMID:16357870</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Li, H]]
 [[Category: Wang, H]]
+[[Category: Histone binding]]
+[[Category: Transferase]]
+[[Category: Zinc finger]]