4ra2: Difference between revisions
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''' | ==PP2Ca== | ||
<StructureSection load='4ra2' size='340' side='right' caption='[[4ra2]], [[Resolution|resolution]] 1.94Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ra2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RA2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RA2 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoprotein_phosphatase Phosphoprotein phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.16 3.1.3.16] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ra2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ra2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ra2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ra2 PDBsum]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PPM1A_HUMAN PPM1A_HUMAN]] Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.<ref>PMID:16751101</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Phosphoprotein phosphatase]] | |||
[[Category: Liu, H D]] | |||
[[Category: Meng, F G]] | |||
[[Category: Pan, C]] | |||
[[Category: Sun, J P]] | |||
[[Category: Tang, J Y]] | |||
[[Category: Wang, H A]] | |||
[[Category: Wang, W B]] | |||
[[Category: Xiao, P]] | |||
[[Category: Xu, Y F]] | |||
[[Category: Yu, X]] | [[Category: Yu, X]] | ||
[[Category: | [[Category: Metal binding protein]] | ||
[[Category: | [[Category: Phosphorylation]] | ||
[[Category: | [[Category: Pp2c family]] | ||
[[Category: | [[Category: Serine/threonine phosphatase]] | ||
