4ydh: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==The structure of human FMNL1 N-terminal domains bound to Cdc42==

~~The entry~~ 4ydh is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4ydh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YDH OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YDH FirstGlance].

~~Authors~~: ~~Kuhn~~, S., ~~Anand~~, K.~~, Geyer, M~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4yc7|4yc7]]</td></tr>

~~Description~~: ~~The structure~~ of ~~human FMNL1 N-terminal domains bound to Cdc42~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ydh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ydh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ydh RCSB], [http://www.ebi.ac.uk/pdbsum/4ydh PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/FMNL_HUMAN FMNL_HUMAN]] May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.<ref>PMID:21834987</ref> [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Anand, K]]

[[Category: Geyer, M]]

[[Category: Kuhn, S]]

[[Category: ~~Geyer, M~~]]

[[Category: Actin cytoskeleton]]

[[Category: Formin]]

[[Category: Gtpase]]

[[Category: Signalling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==The structure of human FMNL1 N-terminal domains bound to Cdc42==
+<StructureSection load='4ydh' size='340' side='right' caption='[[4ydh]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
-The entry 4ydh is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ydh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YDH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YDH FirstGlance]. <br>
-Authors: Kuhn, S., Anand, K., Geyer, M.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yc7|4yc7]]</td></tr>
-Description: The structure of human FMNL1 N-terminal domains bound to Cdc42
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ydh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ydh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ydh RCSB], [http://www.ebi.ac.uk/pdbsum/4ydh PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/FMNL_HUMAN FMNL_HUMAN]] May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.<ref>PMID:21834987</ref>  [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Anand, K]]
+[[Category: Geyer, M]]
 [[Category: Kuhn, S]]
-[[Category: Geyer, M]]
+[[Category: Actin cytoskeleton]]
+[[Category: Formin]]
+[[Category: Gtpase]]
+[[Category: Signalling protein]]