User:Wayne Decatur/Gal 4: Difference between revisions
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<scene name='70/701975/1d66_firstglance_secondary/2'>Each monomer</scene> of the protein dimer has 3 '''<font color='#f00080'> alpha helices</font>'''. | <scene name='70/701975/1d66_firstglance_secondary/2'>Each monomer</scene> of the protein dimer has 3 '''<font color='#f00080'> alpha helices</font>'''. | ||
The protein <scene name='70/701975/1d66_firstglance/2'>binds as a dimer to a symmetrical 17-base-pair sequence</scene>. Specifically, the consensus Gal4p-binding site is a 17-mer of sequence conforming to the motif below, which has the key feature of | The protein <scene name='70/701975/1d66_firstglance/2'>binds as a dimer to a symmetrical 17-base-pair sequence</scene>. Specifically, the consensus Gal4p-binding site is a 17-mer of sequence conforming to the motif below, which has the key feature of CGG triplets at the ends, separated by 11 bps, 5′-CGG-N11-CCG-3′.<br> | ||
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The DNA binding domain <scene name='70/701975/1d66_firstglance_zn_binding/2'>uses six Cys residues to coordinate the binding of two ions of zinc (Zn(II))</scene>. (In the crystal structure [[1d66]], the zinc ions are actually represented by other members of the same group on the periodic table, the heavier cadmium ions.) The Zn-binding motif lets the structure accomplish more with fewer amino acids, the metals lending an "economy of structure", arranging two small helices to recognize a specific DNA site. <scene name='70/701975/1d66_base_conctacts/2'>Two lysines (17 and 18) make direct base contacts in the DNA major groove with the specified | The DNA binding domain <scene name='70/701975/1d66_firstglance_zn_binding/2'>uses six Cys residues to coordinate the binding of two ions of zinc (Zn(II))</scene>. (In the crystal structure [[1d66]], the zinc ions are actually represented by other members of the same group on the periodic table, the heavier cadmium ions.) The Zn-binding motif lets the structure accomplish more with fewer amino acids, the metals lending an "economy of structure", arranging two small helices to recognize a specific DNA site. <scene name='70/701975/1d66_base_conctacts/2'>Two lysines (17 and 18) make direct base contacts in the DNA major groove with the specified CGG triplets</scene>.<br> | ||
{{Button Toggle NucleicDrumsColorSchemeWcartoon}} {{ColorKey Bases DNA}} | {{Button Toggle NucleicDrumsColorSchemeWcartoon}} {{ColorKey Bases DNA}} | ||
