User:Wayne Decatur/Gal 4: Difference between revisions
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The DNA binding domain <scene name='70/701975/1d66_firstglance_zn_binding/2'>uses six Cys residues to coordinate the binding of two ions of zinc (Zn(II))</scene>. (In the crystal structure [[1d66]], the zinc ions are actually represented by other members of the same group on the periodic table, the heavier cadmium ions.) The Zn-binding motif lets the structure accomplish more with fewer amino acids, the metals lending an "economy of structure", arranging two small helices to recognize a specific DNA site. <scene name='70/701975/1d66_base_conctacts/2'>Two lysines (17 and 18) make direct base contacts in the DNA major groove with the specified CGG triplets</scene>.<br> | The DNA binding domain <scene name='70/701975/1d66_firstglance_zn_binding/2'>uses six Cys residues to coordinate the binding of two ions of zinc (Zn(II))</scene>. (In the crystal structure [[1d66]], the zinc ions are actually represented by other members of the same group on the periodic table, the heavier cadmium ions.) The Zn-binding motif lets the structure accomplish more with fewer amino acids, the metals lending an "economy of structure", arranging two small helices to recognize a specific DNA site. <scene name='70/701975/1d66_base_conctacts/2'>Two lysines (17 and 18) make direct base contacts in the DNA major groove with the specified CGG triplets</scene>.<br> | ||
<jmol> | |||
<jmolButton> | |||
<script>select A,ADE,DA; color [x5050FF]; color cartoon [x5050FF]; select C, CYT,DC; color [xE00000]; color cartoon [xE00000]; select G,GUA,DG; color [x00C000]; color cartoon [x00C000] select T,THY,DT; color [xE6E600]; color cartoon [xE6E600]; select U,URA; color [xCC9900]; color cartoon [xCC9900];</script> | |||
<text>Color Structure by Nucleotide</text> | |||
</jmolButton> | |||
</jmol>{{ColorKey Bases DNA}} | |||
Despite only making base-specific contacts at the ends, <scene name='70/701975/Spacefill/1'>Ga14p is mostly in contact with the DNA for its entire span of the binding site.</scene> | Despite only making base-specific contacts at the ends, <scene name='70/701975/Spacefill/1'>Ga14p is mostly in contact with the DNA for its entire span of the binding site.</scene> | ||
