Connexin: Difference between revisions

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<Structure load='<Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><Structure load='<Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><Structure load='<Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><StructureSection load='2ZW3' size='340' side='right' caption='Caption for this structure' scene=''>

=Introduction=

[http://en.wikipedia.org/wiki/Connexin Connexins] are integral transmembrane [http://en.wikipedia.org/wiki/Protein proteins] that form [http://www.ncbi.nlm.nih.gov/pubmed/7522674 intercellular channels] in [http://www.ucmp.berkeley.edu/vertebrates/vertintro.html vertebrates]. Six connexins form a hexamerical assembly, known as [http://en.wikipedia.org/wiki/Connexon connexon] or hemichannel, may form an intercellular [http://www.uniprot.org/uniprot/P29033 gap junction channel] which spans the two [http://study.com/academy/lesson/plasma-membrane-of-a-cell-definition-function-structure.html plasma membranes] and allows the exchange of cytoplasmic molecules. The importance of electrical and [http://en.wikipedia.org/wiki/Cell_signaling molecular signaling] through gap junction channels is widely recognized . Virtually all cells in solid tissues are coupled by gap junctions, thus it is not surprising that mutations in connexin genes have been linked to a variety of [http://omim.org/entry/121011?search=gjb2%20deafness-causing&highlight=deafnesscausing%20deafness%20gjb2%20deaf%20causing Connexin human diseases], including [http://radiopaedia.org/articles/congenital-cardiovascular-anomalies cardiovascular anomalies], [http://www.mayoclinic.org/diseases-conditions/peripheral-neuropathy/basics/definition/con-20019948 peripheral neuropathy], skin disorders, cataracts, and deafness. Of notice, about half of all cases of human deafness in countries surrounding the Mediterranean have been linked to mutations in the [http://www.uniprot.org/uniprot/P29033 GJB2 gene], which encodes Cx26 <ref name='important'>pmid 24624091</ref>.

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-<StructureSection load='2ZW3' size='340' side='right' caption='Caption for this structure' scene=''>
+<Structure load='<Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><Structure load='<Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><Structure load='<Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /><StructureSection load='2ZW3' size='340' side='right' caption='Caption for this structure' scene=''>
 =Introduction=
 [http://en.wikipedia.org/wiki/Connexin Connexins] are integral transmembrane [http://en.wikipedia.org/wiki/Protein proteins] that form [http://www.ncbi.nlm.nih.gov/pubmed/7522674 intercellular channels] in [http://www.ucmp.berkeley.edu/vertebrates/vertintro.html vertebrates]. Six connexins form a hexamerical assembly, known as [http://en.wikipedia.org/wiki/Connexon connexon] or hemichannel, may form an intercellular [http://www.uniprot.org/uniprot/P29033 gap junction channel] which spans the two [http://study.com/academy/lesson/plasma-membrane-of-a-cell-definition-function-structure.html plasma membranes] and allows the exchange of cytoplasmic molecules. The importance of electrical and [http://en.wikipedia.org/wiki/Cell_signaling molecular signaling] through gap junction channels  is widely recognized . Virtually all cells in solid tissues are coupled by gap junctions, thus it is not surprising that mutations in connexin genes have been linked to a variety of [http://omim.org/entry/121011?search=gjb2%20deafness-causing&highlight=deafnesscausing%20deafness%20gjb2%20deaf%20causing Connexin human diseases], including [http://radiopaedia.org/articles/congenital-cardiovascular-anomalies cardiovascular anomalies], [http://www.mayoclinic.org/diseases-conditions/peripheral-neuropathy/basics/definition/con-20019948 peripheral neuropathy], skin disorders, cataracts, and deafness. Of notice, about half of all cases of human deafness in countries surrounding the Mediterranean have been linked to mutations in the [http://www.uniprot.org/uniprot/P29033 GJB2 gene], which encodes Cx26 <ref name='important'>pmid 24624091</ref>.