Pre-mRNA-splicing factor

Pre-mRNA-splicing factors (Prp) are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing. For details on pre-mRNA-splicing factors see

• Prp8
  
• Prp24
  
• Prp19
  
• Prp40.

3D Structures of pre-mRNA splicing factors

Updated on 20-May-2015

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• Pre-mRNA-splicing factor 2
  • 3beg – hPrp residues 105-219 + Ser/Thr-protein kinase – human
    
  • 2o3d – hPrp P33 subunit
• Pre-mRNA-splicing factor 3
  • 1x4q – hPrp PWI domain - NMR
    
• Pre-mRNA-splicing factor 3B
  • 3lqv, 2f9d, 2f9j – hPrp residues 377-415 + pre-mRNA branch site protein 14
    
  • 2fho - hPrp residues 379-424 + spliceosomal protein P14 - NMR
    
  • 2do5 – hPrp subunit 2 – NMR
    
  • 1x5t - hPrp subunit 4 – NMR
    
  • 1x5u - hPrp subunit 4 RNA-binding domain – NMR
    
• Pre-mRNA-splicing factor 8
  • 3sbt, 4ilh – yPrp RNAseH like domain + A1 cistron-splicing factor AAR2 – yeast
    
  • 4jk7, 4jk9 - yPrp RNAseH like domain
    
  • 4ilj, 4jk8, 4jka, 4jkb, 4jkc, 4jkd, 4jke, 4jkf, 4jkg, 4jkh - yPrp RNAseH like domain (mutant)
    
  • 3e66 – yPrp β-finger domain
    
  • 3e9o, 3e9p - yPrp RNA-binding domain
    
  • 2p87, 2og4, 3sbg - yPrp C terminal
    
  • 3zef, 4i43 – yPrp + A1 cistron-splicing factor AAR2
    
  • 4bgd – yPrp JAB1/MPN domain + pre-mRNA-splicing helicase BRR2
    
  • 4kit – yPrp JAB1/MPN domain + U5 small nuclear ribonucleoprotein helicase
    
  • 4ilg – yPrp JAB1/MPN+RNAseH domains + A1 cistron-splicing factor AAR2
    
  • 4bgd – yPrp JAB1/MPN+RNAseH domains + A1 cistron-splicing factor AAR2 + pre-mRNA-splicing helicase BRR2
    
  • 3lru – hPrp residues 1831-1990
    
  • 3e9l – hPrp endonuclease domain
    
  • 3enb - hPrp core domain IV
    
  • 2p8r – Prp C terminal (mutant) – Caenorhabditis elegans
• Pre-mRNA-splicing factor 9
  • 4dgw – yPrp + Prp 21 + Prp 11
• Pre-mRNA-splicing factor 11
  • 4dgw – yPrp + Prp 21 + Prp 9
• Pre-mRNA-splicing factor 18
  • 2dk4 – hPrp splicing factor motif domain - NMR
    
• Pre-mRNA-splicing factor 19
  • 3lrv – yPrp WD40 domain
    
  • 2bay – yPrp U-box
    
  • 1n87 - yPrp U-box - NMR
    
• Pre-mRNA-splicing factor 20
  • 2i2y – Prp RNA-binding domain + RNA – Streptococcus – NMR
    
  • 2i38 - hPrp RNA-binding domain (mutant) – NMR
    
• Pre-mRNA-splicing factor 21
  • 4dgw – yPrp + Prp 9 + Prp 11
• snRNA-associated-splicing factor 24
  • 2l9w – yPrp C terminal – NMR
    
  • 2kh9 – yPrp residues 115-197 + RNA – NMR
    
  • 2go9 – yPrp RNA-binding domains – NMR
    
  • 2ghp - yPrp RNA-binding domains
• Pre-mRNA-splicing factor 31
  • 2ozb – hPrp + RNA + tri-snRNP
    
  • 3siu, 3siv – hPrp + NHP2-like protein + snRNP
    
• Pre-mRNA-splicing factor 40
  • 1o6w – yPrp WW domain – yeast - NMR
    
  • 2b7e – yPrp FF1 domain - NMR
    
  • 2kfd – yPrp FF4 domain - NMR
    
• Pre-mRNA-splicing factor 43P
  • 2xau, 3kx2 – yPrp + ADP
• Pre-mRNA-splicing factor cwc2
  • 3tp2, 3u1l, 3u1m – yPrp
    
• Pre-mRNA-splicing factor cwc26
  • 2mkc – yPrp + U2 SNRNP component IST3 + Pre-mRNA leakage protein
    
  • 4uqt – yPrp + U2 SNRNP component IST3
    
• Pre-mRNA-splicing factor bud31
  • 2my1 – yPrp - NMR
    
• Pre-mRNA-splicing factor sad1
  • 4msx – yPrp
    
• Pre-mRNA-splicing factor RBM22
  • 2ytc – yPrp RNA-binding domain - NMR
    
• Pre-mRNA-splicing factor RDS3
  • 2k0a – yPrp - NMR
    
• Pre-mRNA-splicing factor URN1
  • 2juc – yPrp FF domain - NMR
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman