2z9k: Difference between revisions
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[[Image:2z9k.jpg|left|200px]] | [[Image:2z9k.jpg|left|200px]] | ||
'''Complex structure of SARS-CoV 3C-like protease with JMF1600''' | {{Structure | ||
|PDB= 2z9k |SIZE=350|CAPTION= <scene name='initialview01'>2z9k</scene>, resolution 1.85Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene> and <scene name='pdbligand=DOZ:'>DOZ</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Complex structure of SARS-CoV 3C-like protease with JMF1600''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
2Z9K is a [ | 2Z9K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z9K OCA]. | ||
==Reference== | ==Reference== | ||
Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:[http:// | Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17981158 17981158] | ||
[[Category: Sars coronavirus]] | [[Category: Sars coronavirus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: zinc-finger]] | [[Category: zinc-finger]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:53:06 2008'' | ||
Revision as of 16:53, 20 March 2008
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| 2z9k, resolution 1.85Å | |||||||||||||
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| Ligands: | DMS and DOZ | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Complex structure of SARS-CoV 3C-like protease with JMF1600
Overview
Five active metal-conjugated inhibitors (PMA, TDT, EPDTC, JMF1586 and JMF1600) bound with the 3C-like protease of severe acute respiratory syndrome (SARS)-associated coronavirus were analyzed crystallographically. The complex structures reveal two major inhibition modes: Hg(2+)-PMA is coordinated to C(44), M(49) and Y(54) with a square planar geometry at the S3 pocket, whereas each Zn(2+) of the four zinc-inhibitors is tetrahedrally coordinated to the H(41)-C(145) catalytic dyad. For anti-SARS drug design, this Zn(2+)-centered coordination pattern would serve as a starting platform for inhibitor optimization.
About this Structure
2Z9K is a Single protein structure of sequence from Sars coronavirus. Full crystallographic information is available from OCA.
Reference
Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors., Lee CC, Kuo CJ, Hsu MF, Liang PH, Fang JM, Shie JJ, Wang AH, FEBS Lett. 2007 Nov 27;581(28):5454-8. Epub 2007 Nov 5. PMID:17981158
Page seeded by OCA on Thu Mar 20 18:53:06 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Sars coronavirus
- Single protein
- Lee, C C.
- Wang, A H.
- DMS
- DOZ
- Atp-binding
- Complex
- Cytoplasm
- Endonuclease
- Exonuclease
- Helicase
- Hydrolase
- Membrane
- Metal-binding
- Nuclease
- Nucleotide-binding
- Nucleotidyltransferase
- Protease
- Ribosomal frameshift
- Rna replication
- Rna-binding
- Rna-directed rna polymerase
- Thiol protease
- Transferase
- Transmembrane
- Zinc
- Zinc-finger
