2za5: Difference between revisions

[[Image:2za5.jpg|left|200px]]<br /><applet load="2za5" size="350" color="white" frame="true" align="right" spinBox="true"

caption="2za5, resolution 2.300&Aring;" />

'''Crystal Structure of human tryptase with potent non-peptide inhibitor'''<br />

2ZA5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=2FF:'>2FF</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Tryptase Tryptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.59 3.4.21.59] Known structural/functional Sites: <scene name='pdbsite=AC1:2ff+Binding+Site+For+Residue+B+1'>AC1</scene>, <scene name='pdbsite=AC2:2ff+Binding+Site+For+Residue+A+4'>AC2</scene>, <scene name='pdbsite=AC3:2ff+Binding+Site+For+Residue+D+3'>AC3</scene> and <scene name='pdbsite=AC4:2ff+Binding+Site+For+Residue+C+2'>AC4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZA5 OCA].  

Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives., Costanzo MJ, Yabut SC, Zhang HC, White KB, de Garavilla L, Wang Y, Minor LK, Tounge BA, Barnakov AN, Lewandowski F, Milligan C, Spurlino JC, Abraham WM, Boswell-Smith V, Page CP, Maryanoff BE, Bioorg Med Chem Lett. 2008 Jan 30;. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18272363 18272363]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 27 07:59:29 2008''