2zd1: Difference between revisions

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[[Image:2zd1.jpg|left|200px]]<br /><applet load="2zd1" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:2zd1.jpg|left|200px]]
caption="2zd1, resolution 1.80&Aring;" />
 
'''Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with TMC278 (Rilpivirine), A Non-nucleoside RT Inhibitor'''<br />
{{Structure
|PDB= 2zd1 |SIZE=350|CAPTION= <scene name='initialview01'>2zd1</scene>, resolution 1.80&Aring;
|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+556'>AC1</scene>, <scene name='pdbsite=AC2:T27+Binding+Site+For+Residue+A+557'>AC2</scene> and <scene name='pdbsite=AC3:Edo+Binding+Site+For+Residue+B+429'>AC3</scene>
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=T27:'>T27</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
|ACTIVITY=
|GENE= gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
}}
 
'''Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with TMC278 (Rilpivirine), A Non-nucleoside RT Inhibitor'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
2ZD1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=T27:'>T27</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+556'>AC1</scene>, <scene name='pdbsite=AC2:T27+Binding+Site+For+Residue+A+557'>AC2</scene> and <scene name='pdbsite=AC3:Edo+Binding+Site+For+Residue+B+429'>AC3</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZD1 OCA].  
2ZD1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZD1 OCA].  


==Reference==
==Reference==
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations., Das K, Bauman JD, Clark AD Jr, Frenkel YV, Lewi PJ, Shatkin AJ, Hughes SH, Arnold E, Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1466-71. Epub 2008 Jan 29. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18230722 18230722]
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations., Das K, Bauman JD, Clark AD Jr, Frenkel YV, Lewi PJ, Shatkin AJ, Hughes SH, Arnold E, Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1466-71. Epub 2008 Jan 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18230722 18230722]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: SO4]]
[[Category: SO4]]
[[Category: T27]]
[[Category: T27]]
[[Category: aids]]
[[Category: aid]]
[[Category: dapy]]
[[Category: dapy]]
[[Category: diarylpyrimidine]]
[[Category: diarylpyrimidine]]
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[[Category: transferase]]
[[Category: transferase]]


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